69 results
-The primary objective is to compare the CYP2D6 phenotype, determined by DM-BT in frail and non-frail elderly (by using Fried definition).-The secondary objective is to correlate individual parameters of frailty (e.g. grip strength) with CYP2D6…
Primary Objective: To investigate in a prospective randomized controlled trial whether intravenous infusion of low doses dobutamine solely peroperative or for 18 more hours postoperative in women undergoing a breast reconstruction by means of a DIEP…
The objective is to investigate whether environmental exposure to livestock farm emissions in the Netherlands poses a health risk among neighbouring residents.
Objective: Determination of cross-reactivity to a newly developed PPD-derivative (F000175918) in previously PPD-sensitized patients. Hypothesis:Since PPD-derivative F000175918 is categorized as a moderate sensitizer, based on pre-clinical…
The objectives of the study are:To determine the pharmacokinetic and pharmacodynamic interaction of a single ascending dose of Xen2174 with bupivacaine, and in one cohort of Xen2174 alone, when administered intrathecally to healthy volunteers and…
This health care evaluation study will compare the ZPH with other, usual forms of care given to frail elderly in the hospital. It will also evaluate the added value of a centre for prevention and recovery (Centrum voor Preventie en Herstel, CPH)
The objective of this study is to assess whether sitagliptin may prevent prednisolone-induced impairment of glucose metabolism and beta-cell function.
The objectives of the study are:To determine the pharmacokinetic profile of Xen2174 in plasma and CSF when administered intrathecally to healthy volunteersTo determine which modalities of pain are affected by treatment with Xen2174 when administered…
The primary objective of this study is to evaluate if there are differences in the tissue-interface pressures, pressures inside the tissues and tissue deformation in the sacral area when volunteers lie on a regular spineboard versus a vacuum…
The primary aim of this study is to gain more insight on the impact of reconstructive surgery on circumcised women (type I, 2 & 3). This study may also used for theorizing about plastic surgery on women who are circumcised.
Primary: Assessment of the short-term effect of a Heat and Moisture Exchanger on tracheal mucociliary clearance in laryngectomized individuals. Secondary: The relationship between clinical assessment, ciliary activity and mucociliary clearance.
In this randomised controlled trial we compare three commonly used preventive methods to reduce the pain on injection op (PIP) with a control group. Our primary goal is to try and establish the most effective and easy to use method for preventing…
To demonstrate that treatment with drotrecogin alfa (activated) 24 mcg/kg/h administered as an intravenous infusion for 96 hours reduces 28 day all-cause mortality in adult patients with septic shock compared with placebo.
The goal of the study is to registrate the cardiovascular, metabolic and thermalstrain during the participation of the WUCC time trial. Besides that we will look at different factors, like the weather, fluidintake and clothing, who possible have an…
Main question:Does a restrictive fluid management during general anesthesia lead to less urinary production?Sub questions:Does a fluid management with colloid fluid during general anesthesia lead to a change in urinary production?Does a different…
The purpose of this study is to monitor whether preicncisional bupivacaine (bupivacaïne 0,5% with epinefrine 1:200.000), infiltration in trocarcincisions reduces postoperative wound pain.
To test if viewing a medical consultation on video leads to comparable psychological and physiological responses to the communication as being a patient in that consultation.
The primary goal is to examine the influence of weather condition on thermal load of an endurance run. Secondary we want to investigate the influence of fluid- and nutritional intake and clothing on thermal load of an endurance run.
To test the hypothesis that ketamine has a modulatory effect on fibromyalgia
The objective of these studies is to identify the primary mechanisms of GC-induced dysmetabolic effects in humans and to find biomarkers that reflect these side effects of GC treatment and which can be followed during therapy and in future clinical…