2769 results
Distinguishing frontal lobe epilepsy from ADHD in terms of working memory.
With this study we will investigate the effects of lumbar sympathetic blockade on ERPF and measured GFR and relative changes in non - invasive hemodynamics measured before and after continuous lumbar sympathetic blockade or splanchnic blockade in…
To provide subjects who have completed participation in a Phase 2 or Phase 3 trial continued access to therapy and to evaluate the long-term safety and tolerability of leuco-methylthioninium bis(hydromethanesulfonate) given in flexible doses of up…
The objective of the study is to investigate if it is possible to predict the clinical outcome of a patient with SCN1A related epilepsy based on the findings of advanced genotyping. We aim to answer the following questions:1. Can clinical outcome in…
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic RVCL disease carriers, in order to find a *biomarker* for disease stage and progression.
Primary objectives:The primary objectives of this trial are:• To show PK similarity of BI 695500 to MabThera® and Rituxan® and of Rituxan® to MabThera® (three-way PK similarity).• To establish statistical equivalence of efficacy of BI 695500 and…
A study on extent-related outcome and complications for degenerative cervical spinal disease has not yet been performed. Results of this study may form the basis for a guideline regarding the extent of fixation in degenerative cervical spinal…
The main objective of this study is to detect potential biomarkers for the differentiation of PD and DLB and the differentiation of PD subtypes by using neuroimaging.
The prevalence of tics, tic-severity and quality of life in 50 patients with Tourette syndrome aged >50 years will be assessed.
To understand the interrelations between muscle related parameters (muscle mass, muscle strength, physical performance), energy expenditure (actual physical activity and basal metabolic rate), and nutritional status (energy intake and protein status…
Primary Objective:To assess whether the clinical efficacy of RPC1063 is superior to interferon (IFN) *-1a (Avonex®) inreducing the rate of clinical relapses in patients with RMS.Secondary Objectives:- To assess the effect of RPC1063 on the…
1. The objective of this study is to aquire knowledge about the development of reactive hyperaemia and inflammatory responses of the skin after shear- force and pressure loading. We want to investigate if patients with diabetes type 2 will develop…
1. Investigate whether per-operative subcortico-muscular (LFP-EMG) coherence can be used as a predictor for favourable surgical outcome in DYS and PD tremor patients undergoing DBS surgery 2. Investigate whether pre-surgical EEG-EMG-coherence and…
To investigate the ability of PF-05089771 to demonstrate analgesic properties in healthy subjects for pre-specified primary endpoints using a panel of pain tests.
Our main objective is to develop and validate body fluid and neuroimaging methodologies to detect CAA during life and establish the contribution of CAA to cognitive decline.
To study the acute effect of HD on global and regional CBF.
High-field (7T) MRI and genetic biomarkers for neurocognitive impairment in type 2 diabetes melltius
The primary objectives: 1. To tailor and apply high-field multi-parametric and functional MRI techniques to identify cerebral biomarkers in DM2 and MetS patients compared to control subjects.2. To examine a specific set of genetic hypotheses in DM2…
Main objectiveTo investigate whether dopamine affects the ability to initiate the correct step in response to a sudden change (improbable picture in a predictable context) in PD with and without FOG. Secondary objectiveTo investigate whether…
The main goal of the VUmc part of the study is to acquire sets of data related to Neurological and Neuromuscular Diseases; in order to build a paediatric digital repository and to develop biophysical modelling and probabilistic modelling.
The purpose of Part A is to investigate how quickly and to what extent Rizatriptan in DFN-10 is absorbed and eliminated from the body (this is called pharmacokinetics). In addition, it will be investigated to what extent DFN-10 is tolerated.In Part…