2054 results
To compare the functional outcome of ORIF with a volar locking plate to closed reduction and plaster immobilisation in patients with dislocated extra-articular distal radius fractures.
To define the amount of dietary protein required to optimally stimulate post-exercise muscle protein synthesis in the older population.To assess whether co-ingesting 1.5 g of free leucine (contained within 15 g dairy protein) along with 15 g protein…
Primary objective:Evaluate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of multiple doses of intravenous (IV) ATYR1940 in adults 18 to 65 years of age, inclusive, with FSHDSecondary objective:Explore pharmacodynamic (PD)…
A study on extent-related outcome and complications for degenerative cervical spinal disease has not yet been performed. Results of this study may form the basis for a guideline regarding the extent of fixation in degenerative cervical spinal…
The goal of the study is whether to establish if application of combined cyrocompression therapy directly postoperative after hip fracture surgery results in a significant reduction in painperception en whether this reduces the morfine consumption.…
What is the cost-effectiveness of referral to MRI compared to usual care by the general practitioner in patients with persistent traumatic knee complaints.
To study the safety and feasibility of adding 6 weeks of orally administered Pazopanib to 25 x 2Gy in 5 weeks preoperative radiotherapy in soft tissue sarcoma patients (to identify the Dose Limiting Toxicity (DLT) and the Recommend Phase II Dose (…
PRIMAIRYThe primary objective of this trial is to evaluate the efficacy of atacicept compared to placeboin preventing new flares in subjects with SLE.SECONDARYSecondary objectives of the trial are:• To evaluate the safety and tolerability profile of…
Primary ObjectiveTo define normal values for synovial thickness in the healthy pediatric knee and wrist on MRI after intravenous gadolinium contrast administration. Secondary ObjectiveTo evaluate possible age-dependent variations in normal values…
Overall Objective: To define the properties of whey, casein, milk protein, as well as soy protein with and without additional leucine to augment post-exercise muscle protein synthesis when co-ingested with a carbohydrate containing recovery drink.…
Objective: non-inferiority in fixation of the SL-PLUS MIA compared to the traditional SL-Plus stem and superiority of the SL-PLUS MIA in terms of bone and muscle preservation and thereby increased patient satisfaction and outcome as measured by PROM…
To understand the interrelations between muscle related parameters (muscle mass, muscle strength, physical performance), energy expenditure (actual physical activity and basal metabolic rate), and nutritional status (energy intake and protein status…
The primary objective is to demonstrate the efficacy using 2 co-primary endpoints (as measured by thechanges from baseline to the end of Week 16 in Western Ontario and McMaster UniversityOsteoarthritis Index [WOMAC] pain and physical function…
Primary objective:1. To assess functional outcome of patients with an osteoporotic vertebral compression fractures after one year of follow-up.Secondary objectives:1. To assess radiological deterioration of sagittal alignment during one year of…
The goal of this stdy is to investigate both antibody responses in an invitro culture system which prevents clearance of antibodies and provides the oppertunity to study the antibodies in an antigen-free environment. This should lead to more insight…
To evaluate clinical and esthetic outcomes and patient satisfaction following single-tooth replacement in the anterior maxilla in patients treated with a collagen matrix (Geistlich Mucograft® Seal) and a free connective tissue graft versus…
This study was set up to examen the bioogical and radilogical efficacy of mifamurtide on metastatic osteosarcoma in order to unveil the true activity of this drug The biological activity is measured through macrophage activation. That's why the…
Primary Objectives: To investigate whether differences exist in the mitochondrial energy generating capacity of skeletal muscle of statin users with SAMS compared to statin users without SAMS and controls (non-statin users).Secondary objectives:2A.…
To determine if electronic drug monitoring adherence feedback in standard care for patients with rheumatoid arthritis starting with a new biological DMARD is effective on medication adherence compared to a usual care group. The second objective is…
The primary objective of the present study is to determine the long-term effect of ACL reconstruction on the knee joint range of motion, stability and the incidence of osteoarthritis. Secondary we will investigate the long-term effects on the…