2422 results
The objectives of this proposal are twofold. First, we intend to test the feasibility of the new concurrent fMRI/TMS setup on real brains of a small group of healthy volunteers. That is, can we indeed evoke fMRI BOLD responses in several functional…
This project aims to study how changes in serotonin alter interpersonal functioning in adults with or without a first degree family member diagnosed with MDD. The primary goal is to investigate the effect of experimentally lowered brain serotonin…
Will a sleep training consisting of CBT in a chronic, psychiatric population with depressive disorder and insomnia lead to a decline of sleeping problems and a increase in sleep quality? Will the results from a normal and non chronic population will…
Primary ObjectivesThe primary objective is to explore the tolerability, safety and treatment response (maintained/improved efficacy), based on total Positive and Negative Syndrome Scale (PANSS) score, of a transition to flexibly dosed paliperidone…
Main: to examine the comparative and combined effects of aggression replacement training (ART) and Risperidone on aggressive behaviours among adolescents with aggression problems ages 14-21 across clinical and non clinical settingsSecondary: to…
Hypotheses of the study:Psycho-education coping skills training is effective in reducing the negative consequences of stigma in people with SMI, in a way thata) quality of life of people with SMI improves;b) social functioning of people with SMI…
The aim of this project is to gain insight in which somatic, cognitive and psychosocialfactors contribute to preservation of functioning, in order to identify older people with potentialrisk of functional decline in an early stage and develop…
To assess whether temporary discontinuation of antihypertensive therapy in mildly cognitively impaired older patients on antihypertensive treatment improves cognitive and psychological functioning.
To examine whether this promising parent intervention can reduce behavioral inhibition and anxiety symptoms in Dutch behavioral inhibited children, and whether parental factors influence the treatment outcomes.
Taking into account the challenges related to treatment of MDD in a PCP setting, a MDD assessment tool for PCPs will be developed with a twofold intent: a) to help PCPs to follow the progress of their MDD patients from the start of the AD treatment…
Extent the current instrument for assessing autism in deafblind individuals with profound intellectual disability by Hoevenaars-van den Boom et al. (2008; 2009) to a protocol with manual for assessing autism in people with visual impairments, less…
The main purpose of the proposed naturalistic pilot study is to compare postsynaptic DA receptor binding (reflecting synaptic DA concentrations) and brain Phe levels in PKU adults with lower blood Phe levels with PKU adults with higher blood Phe…
Primary: To evaluate the safety and tolerability following oral administration of multiple doses of BCI-838 in healthy male and female subjects Secundary:To determine the pharmacokinetic profile of multiple oral doses of BCI-838 in healthy male and…
Primary objective: To investigate whether sleep disturbances during pregnancy and/or in the perinatal period will predict postpartum psychopathology in women with an established diagnosis of bipolar disorder and/or a history of postpartum psychosis.…
The objective of this study is to investigate the acceptance, feasibility and efficacy of cognitive behavioral therapy in reducing ADHD symptoms for adult patients with ADHD and SUD. We will also investigate how substance use and craving are…
To examine whether hearing impaired young adults are sensitised to social stress, whether this related to dopaminergic activity and whether theory of mind could mediate the relationship.
This study aims at validating the 3MDR treatment-protocol, reducing PTSD symptom severity. Other area's in which improvement is expected are memory, attentional processes and anxiety in general.
The purpose of this study is to evaluate patients consulting gastroenterologists regarding their perspectives concerning delicate matters such as sexuality. Would it be helpful if the doctor brings up the subject of SA? And how many patients would…
To examine how sensitive certain (combinations of) EEG parameters are for diagnosing delirium in a heterogeneous group of ICU patients during 24 hours of EEG registration. The delirium assessment by delirium experts will determine which patients…
This research project aims at quantification of the efficacy and (cost-) effectiveness of the Hospital Elder Life Programme (HELP) in the Dutch health care situation. Furthermore, this project will describe and understand the experiences of patients…