7946 results
Intermittent neurogenic claudication due to lumbar stenosis is frequently diagnosed among older persons. Due to an aging population it is to be expected the incidence of lumbar stenosis will increase over time. Patients are operated on because of…
1. To characterize the efficacy of topical Fibrocaps plus gelatin sponge, as compared to gelatin sponge alone, in surgical subjects when control of mild to moderate bleeding by standard surgical techniques is ineffective and/or impractical2. To…
The primary objective of this study is to : Assess the hemodynamic profile of Riociguat in patients with symptomatic pulmonary hypertension associated with left ventricular systolic dysfunction The secondary objectives of this study are to : -…
Our proposed randomized controlled trial is the first making this head-to-head comparison in a *real life* primary care setting in the Netherlands. The primary research question is: does a 12-week combination therapy of open label varenicline and…
The aim of the study is to understand the nutritional status of people with complex multiple disabilitiest through measurement of body composition and nutritients.The primary objective of the study is:What percentage of people with complex multiple…
The objectives of this proposal are twofold. First, we intend to test the feasibility of the new concurrent fMRI/TMS setup on real brains of a small group of healthy volunteers. That is, can we indeed evoke fMRI BOLD responses in several functional…
This project aims to study how changes in serotonin alter interpersonal functioning in adults with or without a first degree family member diagnosed with MDD. The primary goal is to investigate the effect of experimentally lowered brain serotonin…
To evaluate the long-term effects of early intervention in high-risk infants on the basis of the VIP-project.
To determine if FDG PET/CT is performant enough with respect to detecting residual lymph node involvement after chemoradiation in order to omit planned neck dissections in patients with locally advanced potentially operable, N2 and N3 head and neck…
- To investigate the safety and tolerability of posaconazole IV Solution (the test medication).- To study how the test compound posaconazole (the test medication) is absorbed, broken-down and excreted by the body. - To study the effect of the test…
Will a sleep training consisting of CBT in a chronic, psychiatric population with depressive disorder and insomnia lead to a decline of sleeping problems and a increase in sleep quality? Will the results from a normal and non chronic population will…
This study will learn us about the prevalence of asymptomatic urinary retention postpartum, as well as the natural course and complications.
To determine the best dose escalation scheme of dipyridamole added to acetylsalicylic acid, based on the side-effect headache, in patients starting secondary preventive therapy for stroke
The goal of the study is to investigate the difference between heart rate variability in patients with overactive bladder and patients with stress incontinence without overactive bladder, and also the difference in heart rate variability with empty…
Primary Objectives:This study consist of:1) a prospective cohort study in which all patients with esophageal cancer, selected for esophagectomy, and willing to be included in this cohort, are followed to assess their complications, short en long…
The objective of the study is to assess the feasibility and diagnostic yield of OCT guided thrombus aspiration in patients presenting with initial conservative management of non-ST-elevation myocardial infarction (NSTEMI).
Primary Objective: To assess immediate and long-term effects of Mindfulness-based Cognitive Therapy (MBCT) and Cognitive Behavioral Therapy (CBT) in reducing depressive symptoms in patients with diabetes. Regarding immediate effects, we expect that…
The purpose of this study is to investigate the clinical performance of Thoraflex in the treatment of subjects with aneurysm or penetrating ulcer of the descending thoracic aorta.The primary objective of this study is to demonstrate the safety and…
The primary objectives of this study is:* To determine the safety and tolerability of rhHNS via ascending doses administered via a surgically implanted intrathecal drug device (IDDD) once monthly for 6 months, in patientswith MPS IIIA.The secondary…
Primary objectiveTo determine the maximum tolerated dose (MTD) and characterize the dose-limiting toxicities (DLT) of LEQ506 when administered orally on a continuous daily dosing schedule.Secondary objectives* To characterize the safety and…