82 results
Which of 2 feeding strategies for children during chemotherapy induced mucositis is optimal for the patient: an elementary diet, containing only simple macronutrients administered via continuous enteral drip; or total parenteral nutrition.
The aim of the study is to compare two physiotherapeutic rehabiliation strategies (supervised versus less supervised) in patients after hip arthroscopy for FAI and/or labral pathology. The hypothesis is that both groups will equally recover in the…
This study will be performed to test the predictive value of the GFI, the VES-13 and the timed “up and go” test compared to components of PACE in elderly patients of the age of 70 years and above undergoing surgery for a solid tumour.
Phase I testing of ABP-700 alone and with remifentanil co-infusions have shown the ability to produce consistent dose dependent sedation effects with conditions favorable for procedural care including minimal involuntary muscle movement, stable…
The goal of this study is to identify and validate recently discovered and novel biomarkers of pathophysiology, diagnosis, classification, disease activity, prognosis, treatment susceptibility, and treatment efficacy in chronic inflammatory…
Mortality will be lower in patients who do not smoke during treatment of non-small cell lung carcinoma with PD-L1-inhibitors compared to patients who smoke during their treatment with PD-L1-inhibitors.
The main clinical challenge remains to identify patients who may benefit from aggressive local treatment (stereotactic radiotherapy, SBRT) of soft tissue oligometastases: for which patients can systemic treatment be postponed? Patients who are…
We hypothesize that an electronic nose can discriminate the VOC pattern in exhaled breath between patients with non small cell lung cancer (NSCLC) and breast cancer.
The objective of this proof-of-concept study is to test in no-option CLI patients whether ARA 290 (a) reduces limb pain, (b) reduces signs of local and systemic inflammation, and (c) promotes wound healing.
To develop a dosing nomogram of irinotecan in patients homozygous polymorphic for UGT1A1*28 and/or UGT1A1*93 in order to reduce the incidence of severe irinotecan-associated toxicity, defined as febrile neutropenia in the first 2 cycles (amendment…
The gastric balloons are expected to remain in the stomach for approximately four weeks, after which they burst and are fecally excreted. It is further hypothesised that intragastric balloons can provide a surrogate stomach fill, inducing an…
The RAINBOW study: Rheumatoid Arthritis ImplemeNtation of Biological dose Optimization in real World
We hypothesize that a multifaceted implementation strategy can stimulate the use of tight control and bDMARD dose optimization in clinical practice, measured by decreased bDMARD use and non-inferiority on disease activity at 18 months.
Simvastatin (an HMG-CoA reductase inhibitor) induces apoptosis in vitro and sensitizes the myeloma cell to chemotherapy. This is the first clinical trial to test if in vivo there is the same sensitization in relapse or refractory multiple myeloma.
Does lipid accumulation in skeletal muscle and the heart effect mitochondrial function in relation to insulin resistance?
we hypothesize that an electronic nose can discriminate the VOC pattern in exhaled breath between patients with Head and Neck Cancer from healthy controls.
A twice daily intake regimen of aspirin provides a more stable inhibition within 24 hours after intake, compared to a once daily regimen.
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Antipsychotics (haloperidol) can cause acute changes in cardiovascular functions, metobolic parameters and platelet aggregation in elderly patients.
Oral ondansetron reduces the proportion of referred children to a (paediatric) emergency department when added to oral rehydration therapy compared to oral rehydration therapy alone.
Gamma probe and ultrasound guided fine needle aspiration cytology (FNAC) of the sentinel node (SN) is an accurate and sensitive minimally invasive alternative to the gold standard of surgical resection of the sentinel node in melanoma and breast…