4091 results
The above anounced studies suggest that some abnormalities in the Wnt pathway can be expected to affect development and function of the brain, potentially leading to recognizable behavioural phenotypes. Given the key role of APC in the Wnt pathway,…
In this study we want to objectively measure the effect of Pirfenidone on cough in patients with IPF.
Our study will measure several different symptoms/aspects of cellulitis, such as redness, swelling, warmth, pain, fluctuation, ulceration and drainage. Each of these aspects will be scored on a scale of 0-3, adding up to a maximum total score of 21…
The major goal of this study is to develop a systematic and stepwise approach for dry eyes. First, it will be evaluated whether Tes glasses are a diagnostic tool for dry eye diseases. Second, it will be evaluated or it can make a distinction between…
Primary Objectives-To evaluate if mitochondrial dysfunction can be induced in healthy, middle aged subjects, through the use of simvastatin, and whether it can be reversed by oral ubiquinol supplementation. -To validate the techniques NIRS, PpIX-…
A pilot study of the feasibility of 11C-MET as postoperative baseline scan in the follow-up of high-grade gliomas for the detection of tumor recurrence.
Objective: The aim of this study is to assess the validity of the 4MGS and 5STS to determine the functional exercise performance of PF patients.
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic RVCL disease carriers, in order to find a *biomarker* for disease stage and progression.
The objective of this study is to demonstrate the influence of pectus excavatum on the anaerobic threshold during exercise. This could be an objective measurement of exercise intolerance. An objective measurement of exercise intolerance can later…
The proposed studies will investigate the effect of auditory attention on speech comprehension, its relation to listening effort, and the effect of hearing loss on these processes.
The main objective of this study is to understand how the brain selects information using attention: what determines which information is selected and how does this selection occur? An important component of this project will be aimed at researching…
Purpose of the study is to investigate neurocognitive and behavioral development in children of morthers with epilepsy, primary school age, and who were exposed to anti-epileptic drugs in utero. Primary research questions are: 1. what is the nature…
A study on extent-related outcome and complications for degenerative cervical spinal disease has not yet been performed. Results of this study may form the basis for a guideline regarding the extent of fixation in degenerative cervical spinal…
The primary goal of the study is to examine whether fluctuations in cognitive functioning can be measured in daily life. Another goal is to study which factors influence cognitive functioning in daily life. Finally, it will be examined whether…
The overall aim of the proposed longitudinal cohort study is to expand our understanding of health-related work functioning among cancer survivors, who returned to work after first cancer diagnosis and treatment with curative intent during 18 months…
This study primarily aims to explore changes in physical activity pattern and energy expenditure in head and neck cancer patients, during and after treatment with surgery with or without (chemo)radiation. The secondary aim of this study is to gain…
This study aims to assess the acceptability and usability of the ECH system from the perspective of patients, their informal carers and their clinicians in a routine outpatient setting for patients with recurrent depressive or bipolar disorder. A…
The prevalence of tics, tic-severity and quality of life in 50 patients with Tourette syndrome aged >50 years will be assessed.
To evaluate and compare PSA-glycosylation patterns in semen of prostate cancer patients and healthy controls.To correlate PSA-glycosylation patterns in semen with pathological tumour stage and Gleason grade in prostate cancer patients.
1. The objective of this study is to aquire knowledge about the development of reactive hyperaemia and inflammatory responses of the skin after shear- force and pressure loading. We want to investigate if patients with diabetes type 2 will develop…