21 results
The main objective is to pinpoint the biological pathways that set long-term risk of CVD and NDI when epigenetically disturbed during fetal development by (1) establishing a longitudinal cohort of MC twins, (2) defining epigenetic alterations…
The primary objective of this study is to investigate whether the use of the EOS calculator safely reduces antibiotic exposure in newborns with suspected EOS in the first 24 hours after birth compared to the current Dutch guidelines.Secondary…
The primary objective of this study is to determine the relation of delta PO2 (PaO2-tcPO2) and delta PCO2 (tcPCO2-cPCO2) levels to sepsis. The secondary aims are to determine the factors that influence delta PO2 and delta PCO2 and to determine the…
Primary objective: To improve outcome prediction in sFGR by developing a prediction model at the time of sFGR diagnosis and by evaluating specific ultrasound parameters throughout the pregnancy. Secondary objectives: - To increase our knowledge of…
Our main objective is to explore the relationship between nutritional intake, growth, body composition and brain development. Hereby we want to improve our knowledge about how to feed the preterm infant in a way that contributes to a better…
This study's first objective is to assess lung mechanics (measured with FOT) in mechanically ventilated infants, in the clinical practice of the NICU, with intermittent measurements during the entire period of mechanical ventilation. The FOT…
The primary objectives of this study are:- Can EEnG measure colonic motility/activity?- Can EEnG be used to distinguish between healthy subjects and patients suffering from a colonic motility disorder.Secundary objective:- What is the…
Comparison of prenatal and postnatal cardiac function assessed by echocardiography using 2-D, 3-D, pulsed wave Doppler, Tissue Doppler and speckle tracking (strain and strain rate) between fetuses/neonates with structural heart disease, fetuses/…
The aim of this study is to visualize the position and movement of the vocal cords duringnon-invasive respiratory support of preterm infants after birth.
Primary objectiveTo establish whether saliva samples could be used as an alternative for blood samples in the therapeutic drug monitoring for amikacin and flucloxacillin. To meet this objective, a PK mod-el will be developed for amikacin and…
To investigate the effect of FCR during hospital stay, accompanied by FICare, on parental stress at discharge in parents of preterm (born before 37 weeks of gestational age) or ill (for instance with sepsis or small for gestational age) infants…
The aim of this study is to use diaphragmatic muscle activity measurements in premature neonates to develop an algorithm that can quickly identify that the patient has apnoea and then classify it by type (obstructive, central or mixed). This could…
Clinical feasibility of the urine collection device, indicated by staff and parents.
We aim to study the patient specific threshold for arterial blood pressure to maintain adequate cerebral perfusion (CBFV) in the perioperative setting and the association between perioperative abnormalities with postoperative brain damage and…
The primary objective is to determine the difference in median red blood cell velocity (RBV) measured within a time interval of half an hour with dynamic light scattering technology between neonates with and without neonatal late-onset sepsis.
Systems biology is an interdisciplinary approach that systematically describes the complex interactions between all the parts in a biological system, with a view to elucidating new biological rules capable of predicting the behavior of the…
The ultimate goal of our study is to reduce the amount of blood withdrawn for blood gas analysis, especially in the intensive care unit and in neonatal care by replacing regularly used 3 ml blood gas syringes with 1 ml blood gas syringes. The main…
Primary Objective: to develop and evaluate a machine learning (ML) prediction model of brain injury in neonates at high-risk for CP to predict motor, behavioral, and cognitive outcome more accurately.This aim will be achieved by: developing and…
The aim of this study is to evaluate the diagnostic value of sCD14-ST in the diagnosis of neonatal sepsis. The secondary aim is to evaluate whether serial measurement of sCD14-ST after suspected sepsis onset is of additive predictive value for the…
Our main question is: How does GDM brain immaturity affect skills that are critical for later language development? To answer this question, we will assess two skills in GDM infants and compare them to term controls in two independent (separate)…