22418 results
Primary objectiveThe primary objective is to evaluate the effectiveness, safety, and tolerability of increasing doses of tapentadol PR (300 mg per day after run in, up titration to 500 mg per day) versus a combination of tapentadol PR (300 mg per…
The main objective of the first part of the study is the demonstration of 89Zr-cetuximab uptake in non-hepatic tumour lesions. The main objective of the second part is the association between 89Zr-cetuximab uptake in non-hepatic tumour lesions and…
Primary: Safety and tolerability of 2 dosages of ambrisentan. Secundary: Efficacy and PK.
The aim of this research is through feedback to increase physical activity of the patient and get a better distribution of activities over the day.
Primary:Part 1:- to assess the relative bioavailability of the compound in an oral suspension (400 mg) and capsules (5 x 200 mg)- to determine the dose of the compound to be administered as an oral suspension in Part 2 of the study Part 2:- to…
The aim of the study is to improve the clinical care and QoL for patients with COPD. We want to do this by means of the evaluation of the efficacy of pulmonary rehabilitation on cognitive function, mood, anxiety, and QoL in people with COPD. In…
The aim of this study is to compare the effects of anterior cervical discectomy versus percutaneous plasma discectomy on pain, on global perceived effect, functional status and health-related quality of life in a group of patients with cervical…
Primary objective: the primary goal is to investigate the effect of audiobooks on quality of life, general psychopathology, the experienced power of the voices and the burden of the voices.Secondary objective: the second goal is to determine whether…
Assess the efficacy of eculizumab in adult patients with aHUS to control TMA as characterized by thrombocytopenia, hemolysis and renal impairment.
Primary1. To determine whether treatment with an aliskiren-based regimen (in part combined with amlodipine or hydrochlorothiazide) compared to a non-aliskiren based regimen, both on top of non-study BP lowering agents where applicable, reduces the…
Primary: To evaluate the efficacy of prucalopride versus placebo over 12 weeks of treatment in male subjects with chronic constipation.Secondary: To evaluate the safety, tolerability, effect on quality of life and effect on symptoms of prucalopride…
Primary: Long term safety and tolerability.Secondary: Time to 1st flare, number and severity of flares, efficiacy in treating flares, effect on inflammatory markers, immunogenicity, PK.
The aim of the present study is to test whether sleep deprivation specifically enhances dissociative symptoms and in doing so, fuels commission errors. It is designed to investigate whether 36 hours of sleep deprivation increases deficits in memory…
The objective of this study is to compare coronary artery plaque characteristics between non-invasive MSCT, and invasive IVUS and OCT in patients presenting with ACS without ST-elevation (non-ST elevation myocardial infarction (NSTEMI)).
The most important objective from this investigation is to prevent or substitute the damage which is coused by therapeutical radiation. As it's most likely that the skin damage as a result of therapeutical radiation can be more limited. From…
* To examine how multiple oral doses of the test compound (an experimental medication) will be taken up by the body, metabolized and excreted by the body in combination with the oral contraception pill which consists of ethinyl-estradiol and…
Assess the efficacy and safety of eculizumab in pediatric patients with aHUS to control TMA as characterized by thrombocytopenia, hemolysis and renal impairment.
This multicentre randomised controlled trial aims to investigate whether PoCUS can be used as an adjunct to improve first attempt success rate in closed reductions of displaced distal radial fractures in adults in the ED.
To identify whether a short axis approach (SAA) or a long axis approach (LAA) to ultrasound guided peripheral cannulation is superior when performed by ED nurses without prior ultrasound experience.
The objectives of this exploratory trial are:1. To measure the pharmacodynamic (PD) effect on parameters derived from 24-hpH/impedance (MII) monitoring,2. To explore the effect on symptoms,3. To evaluate the safety and tolerabilityof treatment with…