22393 results
To determine whether a strategy of invasive treatment (relative to continued medical treatment) of patients with type 2 diabetes mellitus, mild symptoms of stable angina pectoris, and documented myocardial ischemia lead to a decrease in cardiac…
To test the effectiveness of a self help booklet without therapist guidance vis-à-vis a psycho-education brochure for adult problem drinkers in the general population.
Based on previous studies, we will expect that ambroxol improves neurological manifestations in patients with GD3.
A 10% point difference between the intervention group and control group in IDM is expected. The sample size calculation is based on a worst-case scenario with regard to precision. For a binomial distribution, the widest distribution and thus largest…
It is expected that the CFS patient gets more insight in his or her physical activity pattern, intentions develops to change the behaviour, and really changes the behaviour resulting in a reduction of the CFS complaints.
We hypothesize that the underlying mechanisms of the varying response in multiple parameters within an individual can be attributed to variability in the causal path between drug administration, drug tissue distribution, and tissue receptor…
"The primary objective of this study is to evaluate the fixation and migration patterns of the Persona Partial Knee (Zimmer Biomet, Warsaw, IN) in vivo, using model-based radiostereophotogrammetric (mRSA) analysis. The secondary objective is to…
1) The checklist 'Attune & Stimulate' is a valid instrument to assess the arousal level of clients with SID. 2) Caregivers who are randomized to the intervention group that is instructed to use the A&S-checklist attune…
Does suppletion of vitamine D3 (cholecalciferol) have an effect on the systolic blood pressure in hypertensive, vitamin D insufficient patients? 1. H0 hypothesis: there is no effect on the systolic blood pressure; 2. H1 hypothesis: the systolic…
We hypothesise that an anti-inflammatory dietary pattern (AIDP) has a beneficial effect on gut microbiome (diversity and permeability), thereby improving global functioning (measured with Outcome Questionnaire 45, OQ-45), and health of patients with…
A single PRP injection result in a clinical relevant reduction of the complaints at six months, compared to an injection with saline.
To study the effect of the interaction of cyclooxygenase-2 (COX-2) inhibition (started preoperatively and continued 5 days into the postoperative period) and extended local anaesthetic blockade via paravertebral block on postoperative central…
The induction of immunity might be slower in older persons than in younger individuals. This could influence the occurence of adverse events induced by the vaccine.
In the first 6 months Liraglutide affects weight more than CBT, but CBT provides weight maintenance after 12 months.
Nonsimultaneous current steered pulse trains will lead to a single pitch percept whilst reducing the amount of current in comparison to conventional monopolar stimulation
To evaluate whether a dietary advice of green vegetables, beef and whole dairy products during six months including standard supportive care can decrease the TSH-level compared to standard supportive care alone in children aged 1-18 years with…
Non-inferiority (defined as < 12.5% increase) of pooled buffy coat-derived PR platelet concentrates (PR-plasma-PCs) compared to plasma (plasma-PCs) in terms of clinical efficacy determined by WHO grade ≥ 2 bleeding complications.
Background: Multiproblem young adults (between ages 18 and 27), characterized by a variety of severe psychosocial problems, comprise a societal challenge with high priority on the political agenda, both nationally and internationally. However, so…
We hypothesize that treatment with peppermint oil will lead to a greater symptom (especially abdominal pain) reduction in IBS patients compared to placebo. This will lead to a higher total percentage of responders (as defined by FDA/EMA…