287 results
We hypothesize that the underlying mechanisms of the varying response in multiple parameters within an individual can be attributed to variability in the causal path between drug administration, drug tissue distribution, and tissue receptor…
The COL3A1 polymorphism is a inheritable genetic defect, responsible for the increased susceptibility to pelvic organ prolapse in women.
Fatigue affects central nervous system function and, in the setting of the medical profession, could influence specialist performance, patient care and safety. ln contrast to other industries, for example the aviation industry, there are no "…
For cochlear implanted (CI) patients speech recognition in noise still remains one of the most challenging tasks. One way to improve performance in noise is to benefit from binaural hearing (hearing with two ears). For individuals with residual…
1. We first propose that in advanced TC, not only tumor-associated macrophages (TAMs), but also circulating monocytes and bone marrow (BM) myeloid progenitors are functionally reprogrammed by tumor-derived metabolites even before their recruitment…
The primary objective of this study is to review the prevalence of pelvic organ prolapse after laparoscopic hysterectomy compared to vaginal hysterectomy. Because the uterosacral ligaments are the important structure for vault suspension after…
Several reasons for clozapine discontinuation are known, but the current evidence identifying patients who are at risk of discontinuation of clozapine is small and not always consistent. Also cultural differences may question if international…
We hypothesize that socioeconomic inequalities in diet quality are partly explained by differential dietary costs.
Intraoperative verification of paranasal sinus malignancy resection with cone-beam computed tomography will lead to a higher rate of radical resection
The aim of this study is to develop and validate an age-specific checklist that can help clinicians to identify elderly patients with personality disorders in need of highly specialized mental health care.
A dual mobility cup with a small size head (22 mm) is more likely to result in intraprosthetic dislocation than a bigger size head (28 mm).
Vitamin D plays an integral role in calcium and phosphorus homeostasis. A low vitamin D status can occur as a result of reduced synthesis due to lack of sun exposure, decreased intake or absorption, increased hepatic catabolism, or decreased…
More than in any other field, the nature of healthcare, makes that the consequences of human error can take an immense size. Increasingly, people state that complaints and claims in healthcare increase and accrue. Nevertheless, recent research into…
We hypothesize that 18F-FDG is a valide marker for metabolic activity in adipose tissue and even more pronounced in type 2 diabetes.
Type and intensity of the tasks trained influence the training effects while using a myo-electric prosthesis.
Prior studies have shown reagent dependent differences in sensitivity to circulating clotting factor VII (FVII). This reagent dependent sensitivity to FVII can explain the INR differences between laboratory methods and point-of care devices found in…
PD-L1 is up to now the only marker that has been validated for the selection of patients treated for non-small cell lung cancer who might benefit from the treatment with PD-1/PD-L1 inhibitors. Thus far, PD-L1 status is assessed with histology, being…
Patients undergoing breast conserving surgery in combination with oncoplastic surgery are more satisfied with the cosmetic result and have a higher quality of life
Knee OA is characterized by the presence of crepitus (knee sounds). Therefore, this device is able to record these sounds, while the subject is doing a knee movement, and screen for the presence or absence of osteoarthritis.
In the Netherlands, 90% of the patients with gout are managed by general practitioners but most research has been done in secondary care. In primary care there are questions on the clinical relevance of long-term uric acid lowering treatment of gout…