1905 results
The aim of the study is to understand the nutritional status of people with complex multiple disabilitiest through measurement of body composition and nutritients.The primary objective of the study is:What percentage of people with complex multiple…
The main goal of this project is the elucidation of the mechanism underlying the paternal inheritance seen in SDHD- and SDHAF2-related paraganglioma. The results of this project should aid us in the identification of the *modifier* gene, essential…
The primary objective of this study is to gain more knowledge about the mean and the distribution of mitochondrial oxygen tension (mitoPO2), the mitochondrial oxygen consumption (mitoVO2) and the affinity for oxygen of mitochondrial respiratory…
Knowledge about the physiological metabolism of SCFAs and the interorgan exchange of SCFAs across different abdominal organs in humans is lacking to some extent.To this end, the following objective will be addressed in the current study: -Determine…
To determine prevalence of HPV infection before and after renal transplantation. Secondary objectives are to determine the incidence of HPV infections before and after renal transplantation and the genotype of the HPV infections per time point, and…
The aim of this study is to compare the 16S PCR technique with standard bacterial cultures of infected vascular grafts, mycotic aneurysms and non-infected aortic aneurysms.
We have set prior to the design and implementation of this research a primary and a secondary goal.Primary goal:Testing the validity of the computer model of the coagulation cascade and the related PK / PD model of VKA and heparin for use in…
The gaol of the present study is to determine the role of platelet derived TFPI on coagulation in healthy male subjects (n=10) and in healthy female subjects either using ( n=10) or not using oral contraceptives (n=10). Additionally 8 healthy…
The mission of CHEAP is to evaluate whether a protocol can be developed that enables the GP to detect patients with primary hypertension who are at risk for developing future heart failure.The European Society of Cardiology has recently (2008)…
The ultimate goal of this research is the clinical implementation of a non-invasive test for prenatal fetal genotyping, including fetal sex determination, using cff DNA in maternal plasma, to replace the current standard practice of invasive tests,…
Our primary aim is to develop en perfection the diagnostic accuracy of the non-invasive tests for chromosomal aberrations in maternal blood.
1. Developing novel approaches to determine the clinical significance of UVs. 2. Developing new clinical guidelines and implement them into clinical practice.
Study the mechanisms of BAT activity and the effects of BAT acitivity on energy homeostasis.
To examine cellular damage, intestinal barrier function loss, activation of the Complement system and inflammatory alterations induced by ischemia and reperfusion of the human small and large intestine.Second, we aim to study the consequences of…
1. To assess reference values of a pre-defined set of biomarkers for AKI in *surgical* infants with normal kidney function.2. To determine the incidence of AKI in critically ill infants, according to pRIFLE criteria.3. To evaluate the sensitivity…
Aim of this study is to confirm the results from ex vivo research in humans in a clinical setting. The objective is to perform optical spectroscopy measurements during surgical procedures in vivo, involving resection of either breast, liver or lung…
Accurately identify the molecular/ biochemical 'fingerprints' of the tissue structures and cell types within normal and malignant mucosa from the oral cavity, in particular the edge of the tongue and the floor of the mouth, based on Raman…
Substudy A• Validating the supramaximal SteepRamp exercise test to determine physical fitness in type 2 diabetes patients by correlating the result with a conventional VO2max exercise test and determining the test-retest reliability.Substudy B•…
Objectives: 1/. To study the proarrhythmic effects of intracellular Ca2+ signaling alterations in AF.2/. To study the nuclear Ca2+ signaling in AF.3/. To study the Ca2+-dependent pathways activated in AF and the consequences of the inactivation of…
The principal aim of this project is to identify genetic biomarkers involved in susceptibility for drug-induced liver injury in a set of candidate genes (genes relevant to metabolism of drugs and immune system genes).The results of this study will…