158 results
The primary objective of this study is to build a predictive model in which we can identify which (pheno) type of ALS patients has the most benefit from NIV in improving or maintaining quality of life.
Primary Objective: To investigate if a risk model can be made, based on physical fitness and patient characteristics, to predict the recovery of physical function 6 weeks after total knee arthroplasty.Secondary Objective(s): To explore if this model…
We aim to study the patient specific threshold for arterial blood pressure to maintain adequate cerebral perfusion (CBFV) in the perioperative setting and the association between perioperative abnormalities with postoperative brain damage and…
To implement pre-emptive panel based PGx testing in the LUMC and determine patient benefit of PGx guided drug prescription and dispensing.
To set up a prospective cohort that facilitates evaluation of elective neurovascular treatments and that will serve as a multi-trial platform.
The aim of this proof-of-concept study is to analyze the use of heart rate based variables using the Apple Watch:A) To predict Acute Chest Syndrome in patients hospitalized patients for painful crises;B) To predict painful crises in ambulant…
The aim of this study is to determine the feasibility of perioperative (continuous) remote patient monitoring using Ehealth devices and a daily questionnaire in patients undergoing major gastrointestinal surgery. Additionally, to determine (early)…
The primary objective of this study is to investigate whether the use of the EOS calculator safely reduces antibiotic exposure in newborns with suspected EOS in the first 24 hours after birth compared to the current Dutch guidelines.Secondary…
1. to test differences in movement patterns during a standardized lifting task and gait between patients with chronic low back pain with high central sensitization (CS+), low back pain with low/moderate central sensitization (CS-) and healthy…
(I) Investigating the role of the cholinergic system and CBGTC-loop in the pathophysiology of CD, related to both motor and NMS; (II) Finding a biomarker for DBS efficacy in CD, including motor and NMS.
To evaluate the validity of grip work and self-perceived fatigue measured with the eforto® system for monitoring hip fracture recovery and insight in resilience.
The primary aim of the Routine Outcome Monitoring for Geriatric Psychiatry & Science 2.0 project (ROM-GPS 2.0) is 1) to evaluate treatment outcome for affective disorders in specialised geriatric mental health care and 2) to examine the…
Individualized trajectories of upper arm disease progression in Duchenne muscular dystrophy patients
Main objective1. To assess the longitudinal trajectories of upper arm flexor muscle MRI parameters, muscle force and upper arm function in a cohort of ambulant and non-ambulant DMD patients, to assess the value of this muscle as target for…
To develop an exergame system which helps patients, ICU staff (including physiotherapists), in ameliorating early mobilisation exercises (frequency, intensity and patient and staff experience), finally aiming to accelerated rehabilitation and reduce…
The primary objective is to explore whether central sensitization and/or abnormal CPM responses are present in (a subgroup of) patients who will receive shoulder arthroplasty for osteoarthritis, and whether shoulder arthroplasty produces change in…
Alveolar cleft repair using osteoinductive ceramics in children with unilateral cleft lip and palate
To provide for evidence that calcium phosphate based scaffolds generate equal amounts of residual bone volume compared to the use of autologous bone grafts in unilateral alveolar cleft grafting. A secondary objective is to prove that calcium…
This study evaluates the impact of the various outcomes of prenatal exome sequencing (definitive diagnosis, probable diagnosis and incidental findings) on clinical decision making and on parental psychological wellbeing, compared between different…
The main objective of this study is to determine how well the Multiple Screener© can differentiate between patients with no cognitive deficits, mild cognitive deficits and cognitive impairment. Additionally, we aim to confirm the observed accuracy…
Our overall aim is to study how different pathological mechanisms in cerebral SVD influence WMH shape.Primary objectiveTo study the association of a more complex WMH shape with abnormalities in small vessel morphology.Secondary objectiveTo study the…
The objective of this study is to:1) explore the feasibility (recruitment, adherence, and absence of major technical problems) of using both medical-grade and consumer grade wearables for continuous measurement of physical activity, posture, balance…