153 results
The primary aim of this split-mouth randomized clinical trial is to assess accuracy of bracket positioning of a fully digital IDB workflow compared to a DBB workflow, with IDB bracket planning serving as reference for both methods. The secondary…
The primary objective is to examine whether changes over time in monitoring measures of cognition and behavior are associated with functional outcomes in pediatric oncology groups. Additional objectives are to examine trajectories, risk factors, and…
To assess the PK/PD relationship of prednisolone regarding toxicity as clinical outcome in paediatric patients with autoimmune or autoinflammatory diseases
Virtual reality hypnosis is similarly effective in comparison to conventional medical hypnosis in reduction of pain and anxiety throughout needle related procedures in children in a clinical setting.
Tones vs. neutral self-voice (EEG experiment 1 in Session 3; Pinheiro et al., 2018): a) no effect of HP on N100 suppression for self- and externally generated tones as we would expect alterations in sensory feedback only with regards to one’s own…
PRIMARY OBJECTIVE: -To assess the antibody response after mRNA (Pfizer, Moderna) SARS-CoV-2 vaccination in children with cancer SECONDARY OBJECTIVES: To assess in children with cancer after SARS-CoV 2 vaccination: - durability of…
Objective: Our primary objective is to investigate whether proton MRI can be used to supply us with new relevant information regarding the small airways and lung mechanics that cannot be obtained with functional tests. This new information might…
The two objectives of this study are: 1) validation of two questionnaires, the Misophonia Screening List - Child and Youth and the Amsterdam Misophonia Scale-Youth (AMISOS-Y), in order to screen adequately for misophonia 2) testing the effectiveness…
The objective of this study is to elucidate unique and shared impairments across a broad range of social cognition tasks (at the behavioral, neuropsychological, and neurophysiological level by means of EEG recordings) related to subdimensions of…
Objective: To show the protective value and to measure cost effectiveness of higher Ig dosing on progression of lung disease in PAD.
To investigate the prevalence and existence of orofacial abnormalities, in patients with Mucopolysaccharidoses and Mucolipidosis type II and III and how these abnormalities impair the quality of life.
The main objective of this study is to identify similarities and/or differences in social cognition between males and females with ASD at the behavioral, neuropsychological, and neurophysiological level during adolescence.
Phase 1Primary Objective• To determine the RP2D and, if applicable, the maximum tolerated dose (MTD) of NVL-520 in patients with advanced ROS1-positive solid tumorPhase 2Primary Objective• To evaluate the ORR of NVL-520 at the RP2D in patients with…
The aim of this PMCF study is to confirm the clinical safety and performance aspects of intracranial catheter placements forthe medical indications, hydrocephalus of any origin or ICP elevation. The study design requires determination of…
Primary Objectives:• To assess the efficacy of soticlestat in reducing major motor drop (MMD) seizure frequency as add-on therapy to SOC as compared with placebo during the full treatment period (titration + maintenance).For European Medicines…
Primary-To evaluate the safety and tolerability of a single dose of EDIT-101 when administered to participants with LCA10-IVS26 mutationSecondary-To evaluate different doses of EDIT-101 for subsequent clinical evaluation-To evaluate the efficacy of…
To establish that recovery time from a bronchoprofocation test is faster with HFNC compared to no interfention
To evaluate the efficacy of GSK3511294 100 mg (SC) every 26 weeks versus maintaining existing treatment with either mepolizumabor benralizumab in participants with severe asthma with an eosinophilic phenotype who have previously benefited from anti-…
To confirm an age-adjusted optimum dose of efgartigimod IV and provide (model-predicted) evidence for a treatment response.
to investigate the effect of a pre-operative fasting diet on post-operative recovery after renal tumour surgery