1101 results
The main objectives of this study are: • To gain insight into the effectiveness of the Healthy Working Approach on need for recovery in elderly care workers over one year. • To gain insight into the process of implementing the Healthy Working…
The lifestyle program will improve the quality of life and lifestyle behavior, and will decrease the healthcare utlization, comorbidity and cancer recurrence rates.
We hypothesise that an anti-inflammatory dietary pattern (AIDP) has a beneficial effect on gut microbiome (diversity and permeability), thereby improving global functioning (measured with Outcome Questionnaire 45, OQ-45), and health of patients with…
We hypothesize that PARP inhibitors can potentiate radiation-induced tumor cell death in patients treated with PRRT. To determine the maximin tolerated dose (MTD) of this combination, a phase 1 dose-escalation study is needed.
Primary Objective: 1.To investigate whether daily electrical stimulation of gluteal and hamstring muscles combined with usual care is more effective in reducing recurrences of PUs than only usual care in individuals with chronic SCI, who often have…
The aim of this study is to evaluate the effects of platelet transfusions on hemostatic parameters in thrombocytopenic hematology patients and to identify other determinants of hemostasis, which may contribute to clot formation and clot strength.
We hypothesize that there will be a significant difference in anterior translation of the humeral head between patients and healthy objects. Secondly we hypothesize that the inter- and intra-rater reliability of the HHC test will be fair to good.…
The primary objective is to investigate the effectiveness of a personalized 2-year multidomain lifestyle intervention on cognitive performance in older adults at risk of cognitive decline.
It is hypothesized that the orientation of the lower limb joints are not parallel to the walking direction and that a standing measure is highly correlated with the orientation during the standing, load bearing, phase of the gait cycle.
The hypothesize is, that treatment with induction chemotherapy will lead to a 15% increase of the R0 resection rate compared to treatment with neoadjuvant chemoradiotherapy and surgery alone.
European randomised controlled multi-centred implementation trial amongst 24,000 individuals, at high risk for developing lung cancer, evaluating whether it is safe to have risk-based less intensive screening intervals after a negative baseline CT.
We hyopthesize that in SCCH patients 3-monthly pamidronate decreases locally increased bone turnover (measured by Na18F-PET scans) and thereby decreases pain, and leads to improvement in shoulder girdle function, quality of life, physical and work…
Primary: To explore the pharmacokinetics of insulin aspart after pulsed intra-vaginal delivery using the MedRing and after subcutaneous injection in women with T1DM. Secondary: To assess the safety and short-term tolerability of insulin aspart after…
1. There will be a significant improvement in cognitive control, attention bias and memory bias performance after completion of the selected training module in the active vs. control training. 2. Rumination and depressive symptom severity will…
It was hypothesised that the smartphone-administered eQoR-15NL has comparable measurement properties (i.e. measurement equivalence) compared to the paper-based QoR-15NL questionnaire.
We hypothesize that the use of the CD40 agonist mitazalimab (also known as JNJ-64457107 and ADC-1013) may convert pancreatic adenocarcinomas into immunological hot tumors by T-cell-dependent and T-cell-independent mechanisms. Dendritic cell therapy…
Gait quality improves after cruciate-retaining TKA, but will still be abberant compared to healthy, age-matched controls. We will quantify the quality of gait using different metrics related to the specific testing condition. As a primary hypothesis…
We expect that the test characteristics of saline infusion sonography will be higher than the test characteristics of the transvaginal ultrasound. We expect that the saline infusion sonography is less painful and has a lower complication rate than…
The primary objective is to compare the effectivity of buprenorphine/naloxone and methadone on self-reported opioid misuse. Secondary objectives include comparing the effects on pain, well-being, functioning, and medication use.
This is a FIH study for M528101. We expect that the compound is safe and tolerable.