1236 results
The detection rate of the ICG method to identify the SLN in breast cancer patients is not inferior to the standard 99mTc method.
The main objective of the study is to assess the change in first morning void urine albumin-to-creatinine ratio across the study period. The secondary objective is to assess changes from baseline in systolic blood pressure, body weight, eGFR and…
To determine which patients, individually classified for VTE ánd bleeding risk, will benefit from prolonged anticoagulant treatment without being unnecessarily exposed to its risks.
Treatment with Venoruton prevents RVO, which is a surrogate outcome of PTS.
It is feasibility to introduce sleep and activity wearables in hip fracture patients (75+) during hospitalization
In this study we would like to investigate the clinical effectiveness of a smart technology intervention (The Heart Failure Box) in heart failure patients from the department of Cardiology at Leiden University Medical Center.
Investigate the effect of having CYP2C19 and CYP2D6 genotypes at start of antidepressant therapy and it’s cost-effectiveness in the primary care setting.
We hypothesize that the fertility enhancing effect of OSCM during HSGs is also present during THL.
The objective of the PANDORINA trial is to evaluate the non-inferiority of omitting routine intra-abdominal drainage after DP on postoperative morbidity (Clavien-Dindo score ≥ 3), and, secondarily, POPF grade B/C.
"The objective of this study is to evaluate the feasibility and effectiveness of a nursing nutrition intervention (Nurses for Food) on malnutrition in hospital. The intervention will be developed according to the Britisch Medical Research…
The quality of life of adult patients with NMD can be enhanced by providing capability care in comparison to usual care.
We hypothesize that CTC detection through diagnostic leukapheresis improves the detection rate among ER+, N+ primary breast cancer who have received 5 years of adjuvant endocrine therapy and will be a promising technique for risk classification in…
The main hypothesis is that specific mechanisms of action and level of immunosuppressive medication is the most important determinant of SARS-CoV-2 immunity after vaccination or infection in ISP patients.
As this is an explorative design, no formal hypothesis is made. However, our sample size is based on a difference of 2.5% or more in cumulative incidence of serious infections when continuing IA, hypothesizing that patients who continue their IA in…
In patients with recently diagnosed PMR, MTX 25mg/week compared to placebo will lead to a higher proportion of patients in glucocorticoid free remission
Primary Objective: • To investigate whether or not persistent complaints and poor outcome after mTBI be explained by an interaction between physiological and psychological factors. In other words, the aim is to investigate whether a more optimal…
PCT-guided treatment regarding antibiotic use is non-inferior to usual care consisting of prednisolone and or antibiotics, in terms of treatment failure at day 30 for patients hospitalized because of an acute exacerbation of COPD (AECOPD).
Primary Objective: To investigate whether timely delivery of iCBT will lead to a significantly lower mean fatigue severity score (CIS-fatigue) across follow-up visits (T1 and T2) as compared to care as usual. Secondary Objectives: To investigate…
Extracellular vesicles (EVs) in plasma can be used as a biomarker for stroke diagnosis, thereby discriminating between ischemic and hemorrhagic stroke.
Our hypothesis is that macrophages drive ANCA glomerulonephritis by activating T-cells and enhancing their migration towards vasculitic inflammation. Permanent macrophage activation could contribute to chronic elevation of fatigue levels.