985 results
there exist intra & inter patient variability of 17β-HSD-1 and other enzymes involved in the local generation of estrogens
We expect that the development of mitochondrial dysfunction lags behind the development of the hypermetabolic inflammatory state. Additionally, we hypothesize that the aggravation of factors related to the hypermetabolic inflammatory status, such as…
We hypothesize (based on literature) that the incidence of chronic pain in The Netherlands is around 15-20% in patients presenting to the emergency department with (acute) pain related complaints. We have no further hypothesis, because of the…
Effective postoperative pain control is an essential and humanitarian need of every surgical procedure. Inadequate pain control may result in increased mortality, delayed recovery and increased hospital costs (1). The optimal perioperative analgesic…
The goal of this study is to be able to perform reliable measurements on AROM of neck and shoulders , exercise capacity, strength, MMO and functional mobility to evaluate the effectiveness rehabilitation programs in head and neck cancer survivors.
This project aims to determine the validity of a home-based continuous bradykinesia assessment using free typing behaviour analysis. Secondarily, we aim to capture the presence of sequence effect in Parkinson's Disease patients using a computer…
2.1 Primary objectives2.1.1 Cross-sectional part• Technical evaluation of the functional and structural outcome measures to support a biomarker qualification by regulatory authorities and payers. 2.1.2 Longitudinal part • Assessment of prognostic…
The aim of this proposal is threefold: (i) test a neuroscientific model of prosocial development by relating neuroscience discoveries to changes in several dimensions of prosocial development in a comprehensive study including children, adolescents…
(1) To compare adenoma miss rates (AMR) between Endocuff Vision-assisted colonoscopy (EAC) and conventionalcolonoscopy (CC)(2) To compare adenoma detection rates (ADR) between EAC and CC(3) To assess whether a proposed increased ADR and reduced AMR…
To accurately differentiate between metastatic and non-metastatic lymph nodes using light reflectance spectroscopy.
As there are limited data on how to improve outcomes for those patients who do not benefit sufficiently from the availabletreatments, this study aims to compare MBCT to TAU as an adjunctive treatment to reduce depressive symptoms in patientswith…
Calibration of the mitochondrial oxygen tension technique in the human skin
A study to explore three different diagnostic tools (predictors) (tcPO2 measurement, BOLD MRI and DCE MRI) quantifying the degree of tissue perfusion and oxygenation at the intended amputation level in patients with refractory critical limb ischemia…
To compare the level of the sIL-2R between patients who are referred to the Center for Pain Medicine with a suspicion of CRPS but do not fulfill the new IASP Clinical Diagnostic Criteria for CRPS and those who do fulfill the new IASP Clinical…
The aim of this project is to assess the effectiveness of the Untire app in reducing Cancer Related Fatigue (CRF) and improving Quality of Life (QoL) in (former) cancer patients. It further aims to identify the parts of the app that are the…
To determine the within and between variability of pharmacokinetic (PK) profiles in patients treated with DOACs in daily practice
The purpose of Part 1 of the research is to look at the usability and accuracy of the automatically determined CT visualizations and measurements.The purpose of Part 2 of the study is to determine whether the use of the combined information provides…
To assess the benefits and harms of two targets of partial pressure of oxygen in arterial blood (PaO2) in guiding the oxygen administration in acutely ill adults with hypoxaemic respiratory failure at ICU admission.
Primary: To further characterize a cohort of older patients with bipolar disorder, including clinical features, cognition, social functioning, need of care, family history and inflammation markers.Secondary: To investigate the effects of aging on…
To study the efficacy of danazol in patients with pulmonary fibrosis, and to investigate what factors are associated with effective treatment.