65 results
Objectives: 1) to evaluate the effectiveness of the e-CBT-i “i-Sleep” compared to a waiting list condition on sleep efficiency at 3, 6 and 12 months in ACC. 2) to assess the effects of eCBT-I on secondary outcomes: fatigue, quality of life, chronic…
The aim of this proposal is threefold: (i) test a neuroscientific model of prosocial development by relating neuroscience discoveries to changes in several dimensions of prosocial development in a comprehensive study including children, adolescents…
In this study, the aim is to perform a clinical evaluation of the NovioMini in children during behavioural bladder training to examine the performance of the NovioMini as a full-bladder-based notification system during natural bladder filling.
The randomized controlled trial (RCT) will be performed at Karakter Child and Adolescent*s Psychiatric Hospital and will be implemented at all locations, spread out over three provinces in The Netherlands. The project aims:1. To explore the…
To determine the effect of mutations in the TBL1X gene on TH dependent signalling in liver cells generated from iPSCs.
To establish a healthy control group for microcirculatory parameters for current and future studies on the paediatric microcirculation.
The overall aim of this study is to identify developmental deficits in children with Rolandic epilepsy. If developmental deficits are observed, we hope to determine timing, persistence, and prognostic factors for developmental deficits and improve…
Primary Objective:Determine the relevance, feasibility, reliability (test-retest, inter- and intra-rater) and validity of a selected set of outcome measures in children with mitochondrial encephalopathy. Secondary Objective: Determine in- and…
To evaluate the natural progression of disease over time in USH1B patients using visual field testing and best corrected visual acuity.
The goal of the present research is to test the effectiveness of an interactive virtual reality intervention for children with agression problems. Moreover, it is expected that (1) the VR-intervention will decrease aggressive behavior problems, (2)…
Do neonatal critically ill children aged 9-16 years have problems with visuomotor integration? If yes, which aspects of the visuomotor integration are affected and require a possible intervention?
- What is the echogenicity (quantitative described as z-scores, based on own laboratory values and qualitatively described as Heckmatt gradations) of orofacial muscles (digastrics muscle, geniohyoid muscle, masseter muscle, temporal muscle) in…
The aim is to study the feasibility of a brief, intensive, outpatient group treatment (ERP) for youths with chronic tic disorders/Tourette Syndrome (TS), to improve treatment outcome, daily functioning/quality of life and treatment satisfaction.…
1.3. Study Design Rationale The ATLAS-PPX trial (ALN-AT3SC-009) is a multicenter, multinational, open-label Phase 3 switching study designed to demonstrate the efficacy and safety of fitusiran in patients with hemophilia A or B, with inhibitory…
Primary goal:To provide an overview of long term effects (neurocognitive, behavioral and learning problems) in children with MTHI and to identify specific risk groups with a higher prevalence of more serious problems. This knowledge can contribute…
To gain insight into the biological pathways that are influenced by the CEEx30/31 mutations.
1. To determine the frequency of mutations in known and novel pediatric renal cancer predisposing genes.2. To structurally document phenotypic characteristics of children with renal cancer, to optimize genetic counseling and surveillance and…
The primary objective of this study is to compare the safety, overall tolerability, and virologic response of BCV vs. SoC (i.e., investigator-assigned therapy) for the treatment of AdV infection in high-risk pediatric allogeneic HCT recipients. A…
To examine the effect of a physical activity intervention on executive functioning, mental health and academic achievement in healthy adolescents. The secundaire objective is to examine the effect of a physical activity intervention on physical…
1) To investigate the effectiveness of Multi-family therapy (MFT) versus individual oriented treatment as usual (TAU) on end-of-treatment family functioning of veteran families, as reported by the veteran. TAU consists of supportive counselling or…