8 results
To analyze the number of patients with (germline/somatic) actionable molecular aberrations in patients with relapsed/refractory pediatric tumors for whom no standard treatment or study protocol is available.
This study aims to analyze (micro)structural and functional brain development between the early last trimester fetal and neonatal period with the use of longitudinal MRI sequences and sophisticated post-acquisition processing techniques.…
The aim of this study is to identify genetic determinants that are associated with successful immune tolerance induction in patients with haemophilia A and inhibitors.
Primary• To determine the RP2D of crizotinib in combination with temsirolimus • To determine the safety and preliminary activity of single-agent crizotinib in ALK, MET or ROS1 positive tumors Secondary• To study the preliminary activity of…
The aim of the DONOR study is to define whether OD pregnancies, specifically those in which the fetus has a more distant immunogenetic relationship to the mother, are associated with more abnormal placentation and abnormal vasculogenesis, and…
The aim of this study is to reduce the indication for RT without compromising cure rates. To investigate if intensified consolidation therapy (DECOPDAC-21) compared to standard consolidation therapy (COPDAC-28) can compensate for reduction in RT.
The primary objective of the PIBD-NET inception cohort is to search for factors predictive for outcome, specific severe adverse events (SAEs) and for predictors of response or non-response to therapy. The secondary objective is the identification of…
The Primary Objectives of the Phase 1b are: • To assess the safety and tolerability of carfilzomib, alone and in combination with induction chemotherapy, for the treatment of children with relapsed or refractory ALL • To determine the maximum…