2372 results
Primary ObjectivesPart A: RO6874281 Dose Escalation as a Single AgentThe primary objectives for this study are as follows:* To describe the safety and tolerability profile of RO6874281 as a single agent* To determine the maximum tolerated dose (MTD…
The primary objectives of the study are:• To evaluate the effect of 24 weeks treatment with CER-001 on carotid Mean Vessel Wall Area (MVWA) as compared to placebo using 3T magnetic resonance imaging (3T-MRI);• To evaluate the safety and tolerability…
In the MILESTONE study, we will test and evaluate a model of managed transition which contains a planned, purposeful and needsbasedassessment of those who reach the transition boundary at CAMHS. The Transition Readiness and Appropriateness Measure…
The purpose of this study is to test the safety, tolerability and anti-tumor activity of the research study drug, Pembrolizumab (MK-3475) compared to other chemotherapy drugs of physician*s choice (which includes Capecitabine, Eribulin, Gemcitabine…
The objective of the study is to investigate if predictors of cardiac responsiveness are able to predict a renal response to fluid administration in oliguria.
To assess the efficacy and safety of 2 dose levels of NTRA-2112 on intestinal malabsorption in preterm infants as compared to placebo.The sub-study aims to determine whether NTRA-2112 in own mother's milk, donor human milk or preterm formula…
To determine whether AFOs optimized for stiffness in patients with calf muscle weakness are superior to standard AFOs in reducing walking effort, as measured by energy cost of walking (ECW, in Jkg-1m-1), and 2) to build a model to predict required…
Primary Objective: to determine the maximum tolerated dose (MTD) and the associated dose-limiting toxicities (DLTs) of S 81694.Secondary Objectives:- To define the safety and tolerability profile of S 81694;- To define the recommended phase II dose…
Primary objective:To assess the efficacy of PXT3003 compared to Placebo on the disability measured by the ONLS score in CMT1A patients treated for 15 months.Secondary objectives:- To assess the efficacy of PXT3003 compared to Placebo on clinical and…
The main objective of this study is to assess the efficacy of the closed loop system over an extended period. Secondary objectives are to assess the safety of the closed loop system; to determine the time that the control algorithm is active; to…
To assess whether atrial flow patterns during sinus rhythm in patients with atrial fibrillation differ from healthy controls with sinus rhythm.
Managing victimization risks attached to societal participation by people with severe mental illness
The main objective of the study is to gain insight in the effectiveness of the Victoria modules, in terms of acknowledgement for these experiences and risk awareness. These experiences and insights can be used to take acceptable risks in…
The primary objective is to test the hypothesis that endometrial scratching in the cycle preceding controlled ovarian stimulation in women with implantation failure (defined as failure to achieve an ongoing implantation after having completed a full…
The primary aim of the present registry is to assess a risk profile including biomarkers and genetics, associated with failure of the cryoballoon AF ablation, so we can predict failure of the cryoballoon AF ablation. Failure will be assessed within…
Primary objective:- To develop a patient-specific adaptive radiotherapy planning strategy using MRI with more precise target coverage and critical organ sparing by safely reducing treatment margins for resectable esophageal cancer irradiation.…
1. To establish reference intervals for thyroid hormones in plasma at the time of the neonatal screening (day 3-7 of life).2. To establish reference intervals for thyroid hormones in plasma around the 14th day of life.3. To compare the…
The aim of this study is to compare gut-directed hypnotherapy with standard medical treatment in children and adolescents with chronic idiopathic nausea or nausea due to functional dyspepsia. We will examine the effect of these treatments on…
The current study will examine the safety and pharmacokinetic profile of JWH-018.
The primary objective is to test whether thrombolysis with additional contrast-enhanced ultrasound is applicable in patients with peripheral arterial occlusions. The secondary objectives are to investigate the safety of microbubble and ultrasound…
1. To determine the influence of frailty on predicting an increase in HRQL in elderly cardiac surgery patients .2. To develop an AGE score for predicting an increase in HRQL after cardiac surgery based on surgical risk factors, comorbidities and…