2372 results
That patients who have had clinical response or clinical remission after use with Risankizumab can continue using Risankizumab. Also long term safety of Risankizumab will be assessed in patients who were diagnosed with moderate to severe Crohn'…
The primary objective is to investigate the neural correlates of the integration of multisensory information in adolescents with ASD.
Demonstrate whether, in addition to standard of care (SoC), finerenone is superior to placebo in delaying the progression of kidney disease, as measured by the composite endpoint of time to first occurrence of kidney failure, a sustained decrease of…
The primary objective of this study is to investigate the effect of MK-7 supplementation on vascular stiffness in a subgroup of subjects with poor vitamin K status.For this follow-up study the primary objective is to investigate the correlation…
To examine whether providing feedback to patients immediately after scoring in a non-valid range on a SVT would have an impact on subsequent symptom validity and neuropsychological test performance. Furthermore, we examine treatment-outcome as a…
Primary Objective: Test the capacity of drug candidates to specifically inhibit the signalling pathways they target in human blood cells in vitro in the setting of human whole blood.Secondary Objective(s): Test whether drug candidates exert…
1. To investigate the size of the HCHWA-D population by identifying all (possible) mutation carriers and their relatives. 2. Study the genealogy and natural disease history of these carriers.3. Get insight in possible genetic, environmental and…
Primary Objective: Identification of genetic variants causative of CHD. Expression of candidate genes in a zebrafish model. Overall goal is to gain insight in cardiac development by expanding our knowledge of genetic components in de novo and…
Primary objective:The primary objective of this study is to assess the time to painful VOC resolution, measured from the first dose of sevuparine given to achievement of crises resolution, as compared to placebo. Secondary objectives: The secondary…
Primary objective:1) Does individually tailored robotic gait training with the LOPES II result in more reduction of mechanical work during walking and more improvement of gait symmetry than conventional gait training (of similar frequency and…
Primary: To identify whether PCR-proven rhinovirus is a risk factor for prolonged PICU admission in children undergoing cardiac surgery. Secondary: to develop a preoperative algorithm to identify children with increased risk for prolonged PICU…
Determine the efficacy and safety (using objective response rate) of tremelimumab in patients with advanced solid tumors (UBC, PDAC, TNBC).
Efficacy ObjectivesThe primary efficacy objective for this study is as follows:• To evaluate the efficacy of adjuvant atezolizumab treatment in patients with PD- L1*selected muscle invasive urothelial cancer, as measured by disease-free survival (…
To demonstrate that a single intracoronary infusion of autologous bone marrow-derived mononuclear cells in addition to state of the art treatment is safe and reduces allcause mortality in patients with reduced left ventricular ejection fraction (…
Performance of MRK, NexGen and LCS
Total Knee Prosthesis based on AP Stability Measurement and PROMS
Primary objective:Is there a significant difference in Anterior/Posterior stability between MRK, LCS and NexGen total knee prosthesis 1 year post-op?Secondary objectives:Is there a relevant correlation between Anterior/Posterior stability and…
Single-port thoracoscopic sympathicotomy for treatment of raynaud's phenomenon, a feasibility study.
To quantify blood-flow changes after unilateral sympathicotomy
This trial aims to study the effects, costs and cost-effectiveness of an App-based program for women 18 years or older withurinary incontinence (UI) in primary care compared to care delivered by the general practitioner (GP) according to the…
The primary objectives of this study are:* To describe the safety and tolerability of cergutuzumab amunaleukin in combination with atezolizumab* To determine the MTD, if achieved, of cergutuzumab amunaleukin in combination with atezolizumab* To…
The main objective is measuring the initial migration with means of Rontgen Stereophotogrammetric analysis (RSA) of the press-fit cup. The secondary objective is assessing the QoL and long term survival. The hypothesis is that the press fit cup will…
The iBerry Study, phase 2, has two related main study objectives:1) Describing the long-term prognosis of sub-threshold symptoms in terms of course (transition to several full-blown psychiatric disorders, chronicity, recurrence, comorbidity) and…