2372 results
To study cognitive and behavioral outcome and resting-state dynamics in children with a history of perinatal asphyxia before and after the introduction of hyothermia and to compare these data with a group of controls.
The primary objective of this study is to compare the progression-free survival (PFS) of ramucirumab in combination with docetaxel with the PFS of placebo in combination with docetaxel, in patients with locally advanced or unresectable or metastatic…
DDAVP treatment combined with FVIII clotting factor concentrates in patients with mild hemophilia A.
Primary objectives:To assess the proportion of non-severe hemophilia A patients within FVIII target levels with the DDAVP and FVIII concentrate combination treatment in the first 72 hours after the start of combination treatment, without adding off-…
The primary objectives of this study are: 1. To examine the effect of cold acclimation on cardiovascular risk parameters in type 2 diabetic patients. 2. To study if the previously observed effect of cold acclimation on insulin sensitivity in type 2…
This study aims to investigate, using a prospective, longitudinal outcome study design to assess the use of REGENOSS in attaining spinal fusion in patients requiring single-level or 2 level Posterior Interbody Fusion of the lower lumbar spine.See…
The main goal of the study is to assess the incidence of respiratory events using the IPI device.
The primary objective is to evaluate the antitumor activity of ceritinib in patients with ALK-positive NSCLC metastatic to the brain and/or toleptomeninges based on whole body overall response rate (ORR), defined as the proportion of patients with a…
The aim of this study is to compare glomerular filtration rate (GFR) in very long-term TC-survivors treated with chemotherapy, radiotherapy or surgery only and non-cancer treated healthy controls. Furthermore, a secondary aim is to assess prevalence…
Primary Objective: Identification of patient characteristics, echocardiographic measurements and biomarkers that can contribute to a better selection of patients that benefit from percutaneous ASD closure at adult age. Secondary Objectives:-…
A) To investigate the pharmacokinetics and determinants of MTX-PG accumulation in plasma and erythrocytes in adult CNS lymphoma and leukemia patients treated with HD-MTX;B) To investigate whether intracellular MTX levels are related to toxicity in…
Primary objective- To compare the efficacy of liraglutide versus placebo on weight loss in obese paediatric subjects with PWS at 16 weeks and versus no treatment at 52 weeks.Secondary objectives - To compare the efficacy of liraglutide versus…
Obtain normative data within similar age-range as our clubfoot patients.
The objective of the trial is to assess the efficacy and safety of nintedanib in the treatment ofSSc with ILD at a dose of 150 mg bid compared to placebo.
The primary objective is to establish the non-inferiority of the Synergy stent relative to the Xience stent for prevention of MACE. The effect measure is the difference in the rate of MACE in patients randomized to treatment with the Synergy ( index…
The objectives are to evaluate the long-term safety and tolerability profile of aducanumab in subjects with early AD, and to evaluate the long-term efficacy of aducanumab treatment as measured by clinical, radiological and additional assessments…
Objective: The objective of the prospective NAFLD cohort study with biobank is: 1. In a cross-sectional design (a) to determine which factors are associated with the presence of NASH in a population of NAFLD patients and (b) to identify and validate…
The aim of this study is to perform a randomized comparison between ESD and EMR in large (>20 mm) distal non-pedunculated polyps in a Western population. We aim to compare both procedures with regard to recurrence rates and radical (R0)…
1. Investigate health care consumption of patients with bilateral vestibulopathy2. Investigate patient expectations of the vestibular implant3. Define inclusion criteria for vestibular implantation4. Define diagnostic approach for patients with…
Demonstrate whether, in addition to standard of care, finerenone is superior to placebo in delaying the time to first occurrence of cardiovascular mortality and morbidity in subjects with T2DM and the clinical diagnosis of DKD.
The aim of the study is to test the hypothesis that intermittent intravenous paracetamol administration in children after cardiac surgery will result in a reduction of at least 30% of the cumulative morphine requirement.