173 results
The objectives of the trial are to assess whether ABT-414 alone or in combination with TMZ improves overall survival (OS), PFS, tumor response, quality of life, NDFS and steroid use compared to standard treatment with lomustine single agent or TMZ…
To study cognitive and behavioral outcome and resting-state dynamics in children with a history of perinatal asphyxia before and after the introduction of hyothermia and to compare these data with a group of controls.
Primary objective- To compare the efficacy of liraglutide versus placebo on weight loss in obese paediatric subjects with PWS at 16 weeks and versus no treatment at 52 weeks.Secondary objectives - To compare the efficacy of liraglutide versus…
Obtain normative data within similar age-range as our clubfoot patients.
The aim of the study is to test the hypothesis that intermittent intravenous paracetamol administration in children after cardiac surgery will result in a reduction of at least 30% of the cumulative morphine requirement.
Primary Objective: Identification of genetic variants causative of CHD. Expression of candidate genes in a zebrafish model. Overall goal is to gain insight in cardiac development by expanding our knowledge of genetic components in de novo and…
Primary: To identify whether PCR-proven rhinovirus is a risk factor for prolonged PICU admission in children undergoing cardiac surgery. Secondary: to develop a preoperative algorithm to identify children with increased risk for prolonged PICU…
To assess the efficacy and safety of 2 dose levels of NTRA-2112 on intestinal malabsorption in preterm infants as compared to placebo.The sub-study aims to determine whether NTRA-2112 in own mother's milk, donor human milk or preterm formula…
1. To establish reference intervals for thyroid hormones in plasma at the time of the neonatal screening (day 3-7 of life).2. To establish reference intervals for thyroid hormones in plasma around the 14th day of life.3. To compare the…
The aim of this study is to compare gut-directed hypnotherapy with standard medical treatment in children and adolescents with chronic idiopathic nausea or nausea due to functional dyspepsia. We will examine the effect of these treatments on…
The primary objectives of this study is to study the endocrine regulation of growth in preterm infants.Secondary objectives are to study the influence of the endocrine regulation and early nutritional intake on neurodevelopmental outcome, bone…
Primary:To demonstrate the safety of enalapril Orodispersible Minitablets (ODMTs).Secondary:1. To describe the acceptability and palatability of enalapril ODMTs..2. To collect additional information about pharmacokinetics and pharmacodynamics of…
The primary objective is to demonstrate the efficacy of AR101, a pharmaceutical-grade peanut allergen formulation, through reduction in clinical reactivity to limited amounts of peanut allergen in peanut-allergic children (ages 4-17 years, inclusive…
-Evaluate the safety and efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in male subjects <= 17 years of age with cerebral adrenoleukodystrophy (CALD)
To investigate whether an individualized dosing regimen for Thymoglobulin leads to a better immune reconstitution after HCT (definition as in primary endpoint), as compared to historically non-individualized treated patients receiving Thymoglobulin…
to safely reduce antibiotic prescription by a clinical decision rule in febrile children suspected of CAP
To evaluate whether a dietary advice of green vegetables, beef and whole dairy products during six months including standard supportive care can decrease the TSH-level compared to standard supportive care alone in children aged 1-12 years with…
To better understand the progression of early CF lung disease we aim to study lipid profiles and PMN dysfunction in relation to the severity of early lung disease in infants with CF, using BALF samples and peripheral blood. To optimally study these…
Safety ObjectiveThe safety objective for this study is as follows:* To evaluate the safety and tolerability of atezolizumab in pediatric and young adult patients, focusing on the nature, frequency, and severity of serious and non-serious adverse…
Primary objective of this study is to improve identification of epileptic HFOs in EEG and MEG, by comparing them to HFOs in corticography. Secondary objectives are to study the predictive value of non-invasively recorded HFOs for disease activity…