418 results
The primary objective is to determine the impact of HER2 expression in CTCs taken at baseline on outcome to AIs in metastatic breast cancer patients with an ER-positive primary tumor. Secondary objectives are to determine impact of HER2 expression…
The aim of this study is to investigate the differences in organ-specific protein turnover rates by means of stable isotope labelled amino acid infusion in patients undergoing surgery. Primary objective:To compare protein synthesis rates, expressed…
* To estimate the prevalence of hyposalivation and xerostomia in pediatric cancer survivors treated with different cancer regimens (e.g., H&N RT, TBI, CT, or those who developed cGVHD following allogeneic stem cell transplantation).* To…
to assess the pulmonary toxicity in patients treated with cyclophosphamide compared to a control group
To study cognitive and behavioral outcome and resting-state dynamics in children with a history of perinatal asphyxia before and after the introduction of hyothermia and to compare these data with a group of controls.
DDAVP treatment combined with FVIII clotting factor concentrates in patients with mild hemophilia A.
Primary objectives:To assess the proportion of non-severe hemophilia A patients within FVIII target levels with the DDAVP and FVIII concentrate combination treatment in the first 72 hours after the start of combination treatment, without adding off-…
This study aims to investigate, using a prospective, longitudinal outcome study design to assess the use of REGENOSS in attaining spinal fusion in patients requiring single-level or 2 level Posterior Interbody Fusion of the lower lumbar spine.See…
The aim of this study is to compare glomerular filtration rate (GFR) in very long-term TC-survivors treated with chemotherapy, radiotherapy or surgery only and non-cancer treated healthy controls. Furthermore, a secondary aim is to assess prevalence…
Primary Objective: Identification of patient characteristics, echocardiographic measurements and biomarkers that can contribute to a better selection of patients that benefit from percutaneous ASD closure at adult age. Secondary Objectives:-…
A) To investigate the pharmacokinetics and determinants of MTX-PG accumulation in plasma and erythrocytes in adult CNS lymphoma and leukemia patients treated with HD-MTX;B) To investigate whether intracellular MTX levels are related to toxicity in…
Objective: The objective of the prospective NAFLD cohort study with biobank is: 1. In a cross-sectional design (a) to determine which factors are associated with the presence of NASH in a population of NAFLD patients and (b) to identify and validate…
The aim of this study is to perform a randomized comparison between ESD and EMR in large (>20 mm) distal non-pedunculated polyps in a Western population. We aim to compare both procedures with regard to recurrence rates and radical (R0)…
Primary Objective: Test the capacity of drug candidates to specifically inhibit the signalling pathways they target in human blood cells in vitro in the setting of human whole blood.Secondary Objective(s): Test whether drug candidates exert…
Primary Objective: Identification of genetic variants causative of CHD. Expression of candidate genes in a zebrafish model. Overall goal is to gain insight in cardiac development by expanding our knowledge of genetic components in de novo and…
Primary: To identify whether PCR-proven rhinovirus is a risk factor for prolonged PICU admission in children undergoing cardiac surgery. Secondary: to develop a preoperative algorithm to identify children with increased risk for prolonged PICU…
The iBerry Study, phase 2, has two related main study objectives:1) Describing the long-term prognosis of sub-threshold symptoms in terms of course (transition to several full-blown psychiatric disorders, chronicity, recurrence, comorbidity) and…
The primary aim of the present registry is to assess a risk profile including biomarkers and genetics, associated with failure of the cryoballoon AF ablation, so we can predict failure of the cryoballoon AF ablation. Failure will be assessed within…
Primary objective:- To develop a patient-specific adaptive radiotherapy planning strategy using MRI with more precise target coverage and critical organ sparing by safely reducing treatment margins for resectable esophageal cancer irradiation.…
1. To establish reference intervals for thyroid hormones in plasma at the time of the neonatal screening (day 3-7 of life).2. To establish reference intervals for thyroid hormones in plasma around the 14th day of life.3. To compare the…
The exact mechanism behind these dietary influenced modulations of the composition of gut microbiota is unknown. Our hypothesis is that dietary fat intake indirectly causes alteration of the gut microbiota composition, by affecting the function of…