506 results
The primary objective is to demonstrate that detoxification of benzodiazepines in high-dose benzodiazepine dependent patients using continuous subcutaneous infusion of flumazenil is feasible and safe.Secondary goals of the study are to explore 1)…
The main objectives of this study are to (I) investigate characteristics of children and adolescents with CD and/or ODD in comparison with typically developing (TD) controls and (II) examine subtypes of aggression on the behavioural, cognitive,…
To provide subjects who have completed participation in a Phase 2 or Phase 3 trial continued access to therapy and to evaluate the long-term safety and tolerability of leuco-methylthioninium bis(hydromethanesulfonate) given in flexible doses of up…
The primary objective is to evaluate the difference in 68Ga-exendin tracer accumulation in the pancreas of patients with and without complete resolution of T2DM after RYGB by quantitative analysis of PET images.
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic RVCL disease carriers, in order to find a *biomarker* for disease stage and progression.
A study on extent-related outcome and complications for degenerative cervical spinal disease has not yet been performed. Results of this study may form the basis for a guideline regarding the extent of fixation in degenerative cervical spinal…
The primary objective is investigating the effectiveness of *Mindlight* in treating (sub)clinical symptoms of anxiety in children who are diagnosed with an autism spectrum disorder. The secondary objective is to examine the factors that moderate and…
The key objectives of this study are to identify both the genetic background and pathophysiological mechanisms that underlie CSC. To achieve this we will: 1) Perform genetic analysis and ophthalmological examination in a cohort of sporadic CSC…
The goal of this stdy is to investigate both antibody responses in an invitro culture system which prevents clearance of antibodies and provides the oppertunity to study the antibodies in an antigen-free environment. This should lead to more insight…
The project consists of three concrete goals:1)Compare symptoms and patterns of fatigue of visually impaired adults with a control group of adults without a visualimpairment.2)Develop an intervention aimed at treating symptoms of fatigue in visually…
The main objective of this study is the measurement of approach bias in sex offenders and sex addicts, alongside determining whether the approach bias for sexual stimuli differs between these groups. A further objective is to test an intervention…
Primary objective: effectiveness of the SEA exercises in HNC patients with chronic dysphagia, following an exercise protocol of 6 weeks.Secondary objective: feasibility/compliance of the SEA exercises in HNC patients with chronic dysphagia, during…
Investigate the phenotype, function and regulation of TRM in healthy human lung tissue, lung tumors and peripheral blood to improve the understanding of respiratory diseases and adoptive T-cell therapy for lung cancer.
The overall aim of the proposed project is to identify mild PID in elderly patients that distinguish patients with RRTI from individuals with a healthy ageing innate and adaptive immune system. In innate immunity, normal immunosenescence is…
The objective of this study is to analyse the retinal oxygenation in adults with the Oxymap T1 in patients with amblyopia and untreated or treated (vitreo-) retinopathies and compare them to a reference group of healthy eyes of amblyopic and Coats…
* To examine the effects and interactions of individual and environmental factors on the onset and course of mental health problems in adolescents and young adults.* To examine the effects and interactions of individual and environmental factors on…
Primary Objective: Create a complete transcriptome of blood cells from dichotomous HIV-2 infection.Secondary Objective(s): Define host factors and pathways that are implicated in the pathogenesis of HIV infection. Determine of the mechanisms that…
This study had two objectives:1. which factors determine outcome of treatment of children with functional childhood constipation referred to the outpatient clinic of multidisciplinary treatment clinics in the Netherlands;2. which factors can be…
To demonstrate efficacy of adjuvant combination chemotherapy in a randomized phase III trial comparing to no further treatment in the medium and high-risk node negative stage I and stage II patients.
In the future, the determination of CTCs and ctDNA in the CSF could be a new quantitative method for the anti-tumor response assessment of systemic or intrathecal therapy (as opposed to CSF cytology, which is subjective and not a quantitative method…