274 results
A) To investigate the pharmacokinetics and determinants of MTX-PG accumulation in plasma and erythrocytes in adult CNS lymphoma and leukemia patients treated with HD-MTX;B) To investigate whether intracellular MTX levels are related to toxicity in…
Primary: How does the diagnostic outcome of the digital PET/CT study compare to the outcome of conventional PET/CT in patients referred for (re)staging of lung cancer, breast cancer and a group of miscellaneous cancers?Secundary: What is the image…
Primary:To evaluate the clinical activity of GSK525762 in NUT Midline Carcinoma and other solid tumors.Secondary:Effect of treatment with GSK525762 on tumor growth and survival. Pharmacokinetics of GSK525762. Safety.
To evaluate the efficacy of VX-661 in combination with ivacaftor and ivacaftormonotherapy through 8 weeks of treatment in subjects with cystic fibrosis (CF)who are heterozygous for the F508del mutation on the CF transmembraneconductance regulator (…
This proof of principle study is designed to study the excretion of two well-studied transporters, Aquaporin-2 (AQP-2) and the sodium chloride cotransporter (NCC), in urinary exosomes. Both are sensitive to water homeostasis, so that during water…
Primary Objective:The primary objective of this study is to determine whether treatment with JNJ-54861911 slows cognitive decline compared with placebo treatment, as measured by a composite cognitive measure, the Preclinical Alzheimer Cognitive…
The major goal of this study is to develop a systematic and stepwise approach for dry eyes. First, it will be evaluated whether Tes glasses are a diagnostic tool for dry eye diseases. Second, it will be evaluated or it can make a distinction between…
Objective: non-inferiority in fixation of the SL-PLUS MIA compared to the traditional SL-Plus stem and superiority of the SL-PLUS MIA in terms of bone and muscle preservation and thereby increased patient satisfaction and outcome as measured by PROM…
Primary Objective: to investigate whether the variation of the number of lumbar vertebrae in humans is coded by the same genes which are responsible for this as well as in other mammals.
The primary aim of this study is to prospectively assess the incidence of pulmonary embolism in patients undergoing abdominal flap breast reconstruction.
Primary aim:Lymphatic mapping of the neck in oral cavity malignancies using ICG-nanocolloid. Secondary aims:- Analysis of lymphatic drainage of the head and neck area to determine the extension of the neck dissection.- Identification of the tumor…
Is pulmonary function testing using the Whistler device a feasible method in adults with an intellectual disability? Is pulmonary function testing using the Whistler device a reliable method in adults with an intellectual disability? Does the…
The purpose of this study is to investigate the characteristics of different sub cellular constituents in different body fluids of patients with advanced EOC with different histotypes. Besides obtaining more clarity about the role of these…
To determine whether computerized training procedures can lead to a decrease of aggression-related attention andinterpretation, and whether this reduces aggressive behaviors.
Primary objective is to examine the effect of tryptophan supplementation on the number of accepted unfair offers in the Ultimatum Game. Secondary objectives are to examine the effect of tryptophan supplementation on the response bias in a social…
To determine the variability of cognitive features in NF1 and TSC in the absence of genetic variability.
Primary Objective- Compare the safety and efficacy of subcutaneous somavaratan and daily rhGH during 12 months of treatment.Secondary Objective-Evaluate and compare changes in pharmacodynamic responses (IGF-I, IGF binding protein-3 (IGFBP-3), growth…
Primary objective:1. To assess functional outcome of patients with an osteoporotic vertebral compression fractures after one year of follow-up.Secondary objectives:1. To assess radiological deterioration of sagittal alignment during one year of…
To demonstrate that FS laser aided keratoplasty for KC is superior to MALK.
This prospective randomized controlled trial designed to compare the quality of analgesia offered by SFNB and LIA and their effects on morphine consumption, mobilization and pain control postoperatively. Our first hypothesis concerning opioid use is…