2426 results
The primary objective of this study is to investigate the safety of systemic administration of AAV5-hFIX, an adeno-associated viral vector containing a codon-optimized hFIX gene, to adult patients with severe or moderately severe haemophilia B.…
The rationale for performing this clinical study is to gather clinical data to evaluate the safety and effectiveness of the NUsurface device compared to the Standard of Care.
In this study we will identify the role of the endothelial GAGs in Na+ and volume homeostasis. Is there a link between the ESL and individual susceptibility to Na+-excess?
To evaluate the effect of beta 3 adrenoreceptor agonist on urethral pressure variations during filling phase and to initially explore the possibilities for individualisation of treatment for overactive bladder symptoms.
In the current study we examine the effect of a behavioral intervention aimed to improve parental sensitivity on parenting behavior and development of social competence and behavioral control in children. Central questions are: Which parents and…
* To demonstrate efficacy of budesonide (9 mg budesonide/d) vs. placebo for induction of remission in active incomplete microscopic colitis after 8 weeks of treatment* To study the maintenance of remission after end of treatment* To study safety and…
The primary efficacy objective for this study was to evaluate the efficacy of gantenerumab compared with placebo administered to patients by subcutaneous (SC) injection over 100 weeks as measured by the following co-primary endpoints (final outcome…
The primary objective is to identify molecular signatures that can serve as diagnostic and/or severity-of-disease markers for PsA and markers that can predict treatment response in patients with PsA. The secondary objective is to elucidate the…
This study is designed to test the hypothesis that obstructed shunts will function longer after PTA whenever DEB is used instead of the standard balloon used nowadays.
Study Purpose* To continue the evaluation of the safety and efficacy of prophylaxis with BAX 855 for the prevention and treatment of bleeding episodes in PTPs (children and adults from 0 to 75 years of age) with severe hemophilia A.Primary…
Primary Objective(s): 1. Number of positive patients (as determined following histopathological analysis of the excised nodes).Secondary Objective(s): Collection of the below summarized information will provide us an answer to the following…
Primary objectives are:1) To evaluate the efficacy of Xyrem (sodium oxybate) oral solution in the treatment of cataplexy in pediatric subjects with narcolepsy2) To evaluate the safety of Xyrem in the treatment of cataplexy in pediatric subjects with…
To investigate the feasibility of a 10 week (maximum) gait training with DFES in rehabilitation starting in the sub-acute phase after stroke and the initial efficacy on the recovery of spatiotemporal parameters, gait kinetics and kinematics,…
- To evaluate the treatment efficiency by time to progression according to RECIST 1.1
To study the incidence of 'sustained' ventricular tachyarrhythmias in patients with HFpEF.
The objective of the study is to demonstrate the safety and feasibility of the Adagio Cryoablation System in subjects with Atrial Flutter (AFL).
Our global aims are * To improve characterization and classification of TBI in Europe, with inclusion of emerging technologies.* To identify the most effective clinical care and to provide high quality evidence in support of treatment…
To assess the efficacy of the novel kit for the detection of PAMG-1 in the cervico-vaginal secretions of pregnant women with clinically intact membranes presenting with signs and symptoms of PTL in predicting time-to-delivery.
The primary objective of the main non-inferiority study is to determine the safety of TACmono starting nine months after kidney transplantation in immunologically low-risk patients in terms of BPAR-rate 15 months after transplantation compared to…
Primary objectives Phase I: To determine the recommended phase 2 dose (RP2D) of the lapatinib-trametinib combination in patients with KRASm NSCLC Phase II: To determine the progression free survival of the lapatinib-trametinib combination compared…