497 results
Primary Objectives-To evaluate if mitochondrial dysfunction can be induced in healthy, middle aged subjects, through the use of simvastatin, and whether it can be reversed by oral ubiquinol supplementation. -To validate the techniques NIRS, PpIX-…
The main objective of this study is to understand how the brain selects information using attention: what determines which information is selected and how does this selection occur? An important component of this project will be aimed at researching…
Purpose of the study is to investigate neurocognitive and behavioral development in children of morthers with epilepsy, primary school age, and who were exposed to anti-epileptic drugs in utero. Primary research questions are: 1. what is the nature…
This study aims to assess the acceptability and usability of the ECH system from the perspective of patients, their informal carers and their clinicians in a routine outpatient setting for patients with recurrent depressive or bipolar disorder. A…
The prevalence of tics, tic-severity and quality of life in 50 patients with Tourette syndrome aged >50 years will be assessed.
Objective 1To describe the course and underlying mechanisms of dysphagia in children with congenital myopathy (from 6 months to 12 years)Objective 2To formulate recommendations for early detection, diagnostic assessment , treatment and advices for…
1. Investigate whether per-operative subcortico-muscular (LFP-EMG) coherence can be used as a predictor for favourable surgical outcome in DYS and PD tremor patients undergoing DBS surgery 2. Investigate whether pre-surgical EEG-EMG-coherence and…
The main goal of the VUmc part of the study is to acquire sets of data related to Neurological and Neuromuscular Diseases; in order to build a paediatric digital repository and to develop biophysical modelling and probabilistic modelling.
We expect to gain insight in the difficulties in comunication in medical settings. This insight will help to improve the training of doctors and other caregivers. We also think that it can improve interventions directed to prevent and solve problems…
In this study the test characteristics of the early structural ultrasound examination (SUE) (at 13-14 weeks) will be evaluated and compared the those of the standard SUE/AUE at 20 weeks. Also, the amount of (in-)conclusive examinations and the…
The objective of this studie is to gather knowledge about cytokine concentrations (IL-1 *) in the skin of healthy volunteers after the application of shear- force. We want to use this knowledge in the future to investigate if different prophylactic…
Objective: The main objective is to establish the strength of the relationship between improvements in dyspnea and health related Quality of Life (HR-QoL) with the decrease in hyperinflation during the resolution of a COPD exacerbation in the…
To determine the relationship between phenotypic, genetic and biochemical features of AD. , Relevant bimarkers of the skin barrier function including the levels of NMFs, inflammatory mediators (e.g. IL-1 cytokines), SC lipids and serine proteases…
The primary objective of this study is to identify in what manner micro- and macro hemodynamic parameters responds to critical illness and therapy, and to determine how this interaction is related to different states of organ dysfunction (heart,…
The main objective is to investigate if the sensation of children with an upper OBPL is diminished. Both children that were treated conservatively as children that were surgically treated with nerve surgery in early infancy.The primary research…
Post-market clinical follow-up of a magnetic bone conduction implant (Cochlear Baha® Attract System)
This post-market clinical follow-up investigation aims to evaluate the usability and the mid- to long-term performance of the Baha Attract System in terms of hearing outcomes and safety. The objective is to compare the hearing performance with the…
1. To evaluate and optimize a protocol for quantifying brown adipose tissue with MRI and to assess BAT volume per patient. 2. To assess the reproducibility of MRI measurments by determining, inter-scan, intra-observer and inter-observer variability…
The primary objective of this study is to assess the association between pre-dialysis comprehensive geriatric assessment and early death or withdrawal from dialysis (<6 months) in patients aged over 65 years
The purpose of the present study is to improve the estimation of daily energy expenditure and cardiorespiratory fitness, using combined accelerometer and heart rate data under daily life conditions, without the need of a laboratory bound protocol.
To assess the potential of a short neuropsychological test measuring attentional variability and vigilance preoperatively in predicting postoperative delirium among elderly non-dementia patients undergoing elective surgery.