462 results
We study the efficacy of the retractor sponge in laparoscopic colorectal surgery to reduce hospital stay in patients operated for a malignancy. Secondary objectives are duration of surgery, blood-loss,use of diuretics as volume therapy (during…
In this study, we have the following research objectives:1. To examine if NF, by applying the above mentioned AA-protocol, is an efficacious treatment for major depressive disorder. We will conduct a RCT in which active NF will be compared to sham-…
To assure the continued safety and effectiveness of the Tryton Side Branch Stent* with main branch approved DES in the treatment of de novo native coronary artery bifurcation lesions with side branch diameter ranging from >=2.5 mm to <…
The main objective is to study whether patients with elevated levels of LDL show increased H3K4 trimethylation in the promoter regions of pro-inflammatory cytokines and have an augmented ex vivo TLR agonist-induced cytokine production in isolated…
To assess the safety and efficacy, measured as progression free survival, of AZD9291 compared with platinum-based doublet chemotherapy in patients with EGFR mutation positive en T790M mutation positive, locally advanced or metastatic non small cell…
Primary Objective: To determine whether a tobacco product (cigarettes and roll-your-own tobacco) imparts a characterising flavour/odour.Secondary Objective: Do the characterising flavours/odours of the tobacco products as determined through panel…
The first objective of the study is to predict the prevalence of PH in sarcoidosis with pulmonary involvement, and to optimize the diagnostic approach in screening for PH associated sarcoidosis using the RHC as gold standard (Galie, 2009). The…
To determine if electronic drug monitoring adherence feedback in standard care for patients with rheumatoid arthritis starting with a new biological DMARD is effective on medication adherence compared to a usual care group. The second objective is…
The objective of the study is to determine if virtual reality exposure therapy (VRET) is an effective treatment for enhancing social participation in people with a psychotic disorder or generalized social anxiety disorder. The primary objective is…
Primary: to evaluate and compare the efficacy of:1) PDL treatment followed by topical sirolimus application after Er:Yag laser ablation of the stratum corneum in PWS 2) PDL treatment followed by topical sirolimus application without Er:Yag laser…
Primary Objective: - Antibodies to the hepatitis B surface antigen (anti-HBs) levels 30 days after the last hepatitis B vaccine dose (11 months) in children from IBD mothers treated with anti-TNF compared to children from IBD mothers not treated…
This study addresses the following three questions:1. How do fear memories change over time?2. How is the context of fear coded in the brain?3. How can the process of excessive strengthening of fear memory be disrupted
The main objective is to investigate if the sensation of children with an upper OBPL is diminished. Both children that were treated conservatively as children that were surgically treated with nerve surgery in early infancy.The primary research…
Adequate scientific research is needed to assess CSCs impact in: 1) connecting primary care, sport en physical activity and 2) promoting the health of primary care patients. Therefore, the research project consists of two studies.Study I focuses on…
Primary objective: To asses if stenting of the ureteroneocystostomy in living kidney transplantation recipients is necessary to prevent urological complications.Secondary objective: To assess if stenting influences the total amount of urological…
The primary aim of the ISCHEMIA trial is to determine whether an invasive strategy of routine early catheterization followed by optimal revascularization, in addition to OMT, will reduce the primary composite endpoint of cardiovascular death or…
Primary Objectives: 1. To tailor and apply multi-parametric, functional MRI techniques to identify cerebral abnormalities (cerebral biomarkers) in MELAS patients.2. To investigate which cerebral biomarkers are shared and differ between MELAS…
Assess dominant mutations and activation pathways in cervical cancers predictive to standard treatment response.
We aim to examine, in the impaired older population, whether a treatment using methylphenidate, a DA re-uptake inhibitor that enhances DA, improves attention and memory.
Primary objective: to evaluate the image quality between the two protocols using Signal to Noise Ratio (SNR) measurements Secondary objectives: 1) test if measurements of lung volume and central airways dimensions using MRI are related to validated…