2238 results
The primary aim of this study is to validate the paradigms designed to investigate the effects of social stress and reward on in healthy individuals. This will allow us to evaluate and optimize the experimental paradigms in terms of their design,…
Objective of this study is to determine validity, test-retest reliability and discriminant ability of the Mr Cube system to assess coordination and proprioception of the knee joint in patients following ACL reconstruction, patients with patellar…
The primary aim is to investigate the effects of attentional focus manipulation on the performance of a repetitive leg movement task under single and dual-task conditions in ABI patients. Furthermore, it will be investigated to what extent the…
In this study, we will assess the tolerability of GPA in healthy male volunteersFurthermore, we will assess the effect of GPA and creatine on hemodynamic, biochemical parameters and ADP-dependent plateletaggregation of healthy male volunteers.
The primary objective of the study is to confirm that the addition of rindopepimut?GM-CSF to adjuvant temozolomide improves overall survival in patients with newly diagnosed EGFRvIII positive glioblastoma who have undergone gross-total resection.
The effects of cross-education on loss of muscle strength and knee function after ACL reconstruction
Primary Objective:The aim is to compare the effects of rehab with standard care vs. standard care plus XED on loss of muscle strength and function in the operated limb at the end of phase I rehab after ACL reconstruction surgery.
The primary objective is to assess the contribution of HER2-PET to subsequent anti-HER2-therapy decisions. Secondary objectives are assessment of clinical value of HER2-PET for the referring clinician; correlation of HER2-PET with standard…
Primary objective:To assess the two-year prevalence and incidence of clinical relevant arrhythmias in drug-resistant epilepsy.Secondary objective:To assess whether the recorded cardiac arrhythmias are related to epileptic seizures (subjectively from…
The purpose of this study is to demonstrate the effectiveness of renal denervation in lowering blood pressure in patients with therapy-resistant hypertension and end-stage renal disease who are on dialysis or who have a renal transplant.
To demonstrate that food elimination therapy based on component-resolved diagnostics is an effective and acceptable treatment for EoO patients.
This study aims to determine whether early start of oral intake in patients that underwent an esophagectomy is feasible and safe.
To assess the analgesic efficacy, safety, and tolerability of once daily orally administered GRT6005 in a total of 3 fixed doses (i.e., 200 µg, 400 µg, and 600 µg GRT6005) compared to placebo in subjects with moderate to severe chronic LBP.
Primary: To compare the reduction in frequency of partial-onset seizures on each of two trough ranges of everolimus (3-7 ng/mL and 9-15 ng/mL) versus placebo in patients with TSC who are taking one to three AEDs. Key secondary: Ability to completely…
Determining the effect of long-term weight loss after bariatric surgery on:- striatal dopamine D2/3 receptor availability - behavioral parameters- plasma hormones, metabolites and peptides involved in appetite regulation, and glucose metabolism
This study aims to determine the following: * What is the nature and extent of relational and sexual problems of stroke patients and their partners. * What is the time course of the relational and sexual problems of stroke patients and their…
The two primary objectives are to test the hypothesis that (1) structural and functional abnormalities of the fronto-striatal circuits are related to the development of compulsive and impulsive behaviour in ASD and OCD; and that (2) the glutamate…
to develop a *two hit* in vivo autologous RBCs transfusion model in healthy male volunteers.
The main objective of this pilot study is twofold: 1) To investigate whether and to what extent raped adolescents experience symptoms of posttraumatic stress disorder at maximum 18 months of follow-up, measured by standardised questionnaires and…
To investigate the effect of a Dutch Can Do Training (CDT) on self-efficacy in people with Relapsing Remitting Multiple Sclerosis.
We study training effects in patients that receive training in the early CVA-phase (CVA < 6 weeks).Goals:1. Determination of the training effects in the early phase of stroke. 2. Determination of quality of life in trained CVA patients with…