482 results
To investigate if the use of different stimulation protocols / GnRH-analogues affects embryo developmental kinetics after IVF treatment. We hypothesize that GnRH analogues differentially affect embryo development through differences in follicular…
The major objective is to investigate the effects of the GR polymorphisms on metabolism in the skeletal muscle, in order to unravel the pathophysiological mechanisms underlying previously observed clinical effects in carriers of this polymorphisms.…
The International GBS Outcome Study (IGOS) aims to identify the most important clinical and biological determinants of disease progression and recovery in GBS. This information will be used to understand the diversity in clinical presentation and…
The current study aims to evaluate magnetic resonance imaging (MRI)-based CVR measurements with ACZ in SCD. It*s primary objective is to assess whether there is a correlation between CVR with silent cerebral infarcts (SCI) (i.e. the cerebrovascular…
The primary aim of this study is to gain knowledge on the natural course of Dupuytren's disease, in adults with various Dupuytren disease stages. Secondary aims are: - Gain insight in course after treatment- Determine whether there are risk…
To study phenotypic and functional characteristics of hepatic lymphocytes in patients with viral hepatitis or other liver related diseases.
Primary objectives are:To assess the diagnostic accuracy of DWI in the evaluation of disease activity in JIA as compared to contrast-enhanced MRI as the reference standard.To assess the accuracy of DWI in detecting joint inflammation as compared to…
Primary objective To determine the relation between age and pharmacokinetics of docetaxel, paclitaxel, doxorubicin, gemcitabine, vinorelbine and capecitabine, respectively. Secondary objectives All here cited secondary endpoints will be separately…
1- To estimate the prevalence of cardiac abnormalities, defined as systolic dysfunction, cardiovascular risk factors in CCS who have received anthracyclines, mitoxantrone and / or radiotherapy to the heart region compared with sibling controls and…
Primary objective: Are changes in stress-induced autonomic and hormonal parameters associated with (epi)genetic vulnerability for schizophrenia and bipolar disorder?Secondary objectives: 1. Are changes in autonomic and hormonal parameters after…
The PRELHUDE study investigates the reversal of the ZAHARA3 study; whether subclinical congenital heart disease occurs in women who deliver prematurely for unknown reason. The biosamples taken during and after delivery will be used to determine…
The aims of the present study are: 1. to create a tracer kinetic model for quantification of [18F]FCH and simultaneously validate a simplified quantitative method, and 2. to assess the repeatability of the latter method.
We want to describe in detail the MTH-induced changes in pro- and anti-inflammatory markers in patients after CA. We further aim to evaluate the relation between neurological outcome and levels of pro- and anti-inflammatory markers.
1. To establish whether serial exhaled breath analysis using eNose can detect invasive pulmonary aspergillosis in patients with prolonged chemotherapy induced neutropenia (neutrophil counts <0.5 x 10^9 for more than 7 days).2. To establish…
To determine whether perioperative myocardial ischemia is associated with adverse outcome in patients scheduled for major abdominal surgery.
Primary ObjectiveTo define normal values for synovial thickness in the healthy pediatric knee and wrist on MRI after intravenous gadolinium contrast administration. Secondary ObjectiveTo evaluate possible age-dependent variations in normal values…
To identify circulating mediators that are released after surgery and which are responsible for macrophage activation.
The primary objective of this study is to evaluate effectiveness of the Philips Sonalleve MR-HIFU device for the palliation of pain in patients with bone metastases.
Primary objective: To show that the variability of whole blood total and unbound plasma tacrolimus concentrations during the first 6 days post transplantation is larger than the variation of tacrolimus concentrations in stable clinical situation.…
To further investigate the pathogenesis of DCI and its relation to gender, decreased fibrinolysis, increased coagulation, and hormonal factors in order to eventually pave the way for new treatment options.