438 results
The main goal of this project is the elucidation of the mechanism underlying the paternal inheritance seen in SDHD- and SDHAF2-related paraganglioma. The results of this project should aid us in the identification of the *modifier* gene, essential…
To examine whether this promising parent intervention can reduce behavioral inhibition and anxiety symptoms in Dutch behavioral inhibited children, and whether parental factors influence the treatment outcomes.
The primary objective of this study is to gain more knowledge about the mean and the distribution of mitochondrial oxygen tension (mitoPO2), the mitochondrial oxygen consumption (mitoVO2) and the affinity for oxygen of mitochondrial respiratory…
The primary objective of this study is to investigate whether CYP3A phenotype, as measured with midazolam clearance, correlates with cabazitaxel clearance. Our secondary objective is to investigate whether this CYP3A phenotype outperforms BSA as a…
Knowledge about the physiological metabolism of SCFAs and the interorgan exchange of SCFAs across different abdominal organs in humans is lacking to some extent.To this end, the following objective will be addressed in the current study: -Determine…
The research focuses on the active screening of high prevalence patients and the diagnosis of AAA. This study aims to establish an effective screening protocol and determining a higher prevalence in patients with PAD and patients with carotid…
Our overall objective is to better understand the role of regulatory B cells in disease pathogenesis and to better predict disease flares in order to individualize treatment.
To determine prevalence of HPV infection before and after renal transplantation. Secondary objectives are to determine the incidence of HPV infections before and after renal transplantation and the genotype of the HPV infections per time point, and…
At the stroke unit, exposure to the *Dynamic Adaptive Healing Light System* (DAHLS) following a predefined daily rhythm with low, medium or high intensities dependent of the medical status of the ischemic stroke patient is expected to improve the…
The aim of this study is to compare the 16S PCR technique with standard bacterial cultures of infected vascular grafts, mycotic aneurysms and non-infected aortic aneurysms.
Objective 1: to examine the relation in wall thickness and diameter across arteries that are prone (i.e. carotid, femoral, superficial femoral and popliteal) and resistant (i.e. brachial and radial) against atherosclerosis in healthy volunteers and…
Clinical, prospective, non-randomized trialOrbis Medsich Centre, Sittard-Geleen
To enhance the (functional) communicative skills of children/adolescents with severe communicative problems with the use of specialized AAC aids in order to optimize their participation at home, in school and other social contexts.
Primary Objective: Our main goal is to determine whether dislocated distal radius fractures immobilized in dorsoflexion gives a better functional outcome in comparison to immobilisation with the wrist in palmarflexion. For this we will use the quick…
The mission of CHEAP is to evaluate whether a protocol can be developed that enables the GP to detect patients with primary hypertension who are at risk for developing future heart failure.The European Society of Cardiology has recently (2008)…
To study the protective effect of pre-treatment with metformin on flow mediated dilation after 20 minutes ischemia and 20 minutes reperfusion. If metformin treatment indeed limits endothelial IR-injury, a second study will be performed in the same…
To study whether dipyridamole reduces gastrointestinal absorption of metformin.
The ultimate goal of this research is the clinical implementation of a non-invasive test for prenatal fetal genotyping, including fetal sex determination, using cff DNA in maternal plasma, to replace the current standard practice of invasive tests,…
To conduct a feasibility study to test 1) whether focused and intensive dual task gait training leads to sustained improvements in complex gait performance. The study will focus hereby on influencing the ability to resist dual task interference, the…
Therefore, the aim of this study will be to assess reproducibility of pseudo-CASL (p-CASL) between 3.0 Tesla MR scanners of two vendors in two medical centers.