2205 results
The objective of the study is to evaluate the safety and efficacy of eculizumab to prevent AMR in sensitized recipients of living donor kidney transplants requiring desensitization therapy.
To evaluate in detail the functionality of immune cells in the liver and blood in chronic HCV patients before, during and after treatment with telaprevir, pegylated-IFN-alfa and ribavirin.
The primary study objectives are: (1) to determine whether an internet-based guided self-help intervention is effective in reducing symptoms of depression in glioma patients; (2) to determine the impact of the intervention on the HRQOL of both…
This study will answer the question if (repeated) abdominal amnioninfusion after midtrimester PPROM with associated oligohydramnios improves perinatal survival and prevents pulmonary hypoplasia and other neonatal morbidities. Moreover, it will…
The primary objective is to determine the number of subjects that experience a decrease in CDAI (Crohn*s Disease Activity Index) of at least 70 points by the Week 8 or Week 12 assessment.
To assess the short-term (2 hours, and 2 days) effects of the egg protein hydrolysate on arterial stiffness in volunteers, aged 18-70 years with overweight and impaired glucose tolerance (defined as blood glucose >7.0 mmol/l and <11.0…
Optimization of the supplementation of vitamins and minerals1. In patients who received a gastric banding for treatment for their morbid obesitya. Reduction of iron deficiencyb. Reduction of Vitamin B12 deficiencyc. Reduced Vitamin D deficiency2. In…
This study aims to design a nomogram for the course of serum pro-calcitonin in burn patients. For this purpose, a new, sensitive assay will be used. It is expected that the nomogram will help to differentiate between patients with a systemic…
Evaluation of the feasibility of sentinel node detection by PET-CT lymphoscintigraphy
The primary objective is to assess the vitality and process of ingrowth of autologous bone graft in PLIF during the first postoperative year in order to predict intervertebral bony union. The second objective is to assess clinical outcome measures.
To evaluate if Epigallocatechin gallate (EGCG) is an effective treatment for pain in endometriosis patients using oral contraceptives by using Visual Analogue Scores (VAS) * To evaluate if the VAS pain scores are lower after EGCG versus placebo…
To ascertain whether the survival time distribution for patients randomized to the investigational arm is consistent with longer survival as compared to patients randomized to the control arm.
Primary objective of the OPTICARE study is to evaluate whether patients with acute coronary syndrome (ACS) will derive additional benefit from an extended CR program compared to standard CR.
In this study, we want to investigate the effects of a 12 weeks home-based exercise program (treadmill trained and strengthening) aimed to improve the aerobic fitness and muscle strength of patients with JDM. Furthermore, we want to investigate the…
To evaluate the efficacy, safety, tolerability, and pharmacokinetics of bevacizumab when added to postoperative radiotherapy with concomitant and adjuvant temozolomide (TMZ) and to determine whether the addition of anti-angiogenic therapy with…
To compare midazolam pharmacokinetics in morbidly obese patients before/during bariatric surgery and 0.5-2 year after surgery.
The purpose of this study is to evaluate whether thyroid hormone replacement therapy in type 2 diabetic patients suffering from overt hypothyroidism will improve muscular mitochondrial function, lower ectopic fat accumulation in muscle and liver,…
The primary objective of this study is to determine the impact of a diagnosis and type of treatment of cancer, ageing and their interaction on wellbeing of older cancer patients. Furthermore, we aim to determine the different psychosocial…
Our primary objective is to investigate the development of structural and functional connectivity in autism and ADHD in comparison to the typical development of connectivity. A secondary objective is to investigate the effects of ADHD and autism…
To evaluate the long-term safety, tolerability and efficacy of ArikaceTM 590 mg for a maximum 12 cycles administered once daily, where each cycle consists of 28 days on treatment followed by 28 days off treatment.