1551 results
To assess the efficacy, safety and cost-effectiveness of the CYP2C19 genotype guided antiplatelet treatment strategy, using clopidogrel or prasugrel/ticagrelor.
To demonstrate that SCS is capable of treating otherwise refractory neuropathic pain after chemotherapy / radiotherapy.
The goal of this research project is to evaluate effectiveness of a cognitive behavioural therapy self-help intervention offered through the Internet in multiple sclerosis (MS) patients with a co-morbid depressive symptoms. With the online guided…
In this study we will investigate the management of HCA during pregnancy based on a prospectively acquired online database in the Netherlands.
To find out if MEK162 is safe and what effects (good of bad) it has on the patient.. To understand what MEK162 does in the patient and assess what the patient does to clear the studymedication from the system. And last but not least to find out what…
The goal of the trial is to compare the efficacy and costs of bevacizumab 1.25 mg and ranibizumab 0.5mg given as monthly intravitreal injections over 6 months for the treatment of macular edema secondary to a retinal vein occlusion.
Primary objectives:Standard Risk R1: in a randomised trial, to examine whether add-on treatment with fenretinide or zoledronic acid, or zoledronic acid plus fenretinide in addition to induction and maintenance chemotherapy improves event-free…
The STEM study presented here aims to increase our knowledge of the most common intestinal, gastric and liver epithelial diseases with the ultimate goal to treat these disorders. Particularly, children that have severe malfunction of their…
The objective of the study is to investigate the feasibility and efficacy of treatment with lenalidomide and rituximab with or without bendamustine in patients with relapsed follicular lymphoma.
The goal of this study is to collect a large cohort of patients mainly with NSHI. In the study cohort, the genetic causes underlying the NSHI will be determined which can be either in known or novel deafness genes. Also, the clinical characteristics…
1) To identify new predictors of ST, in particular of late and very late ST, and of drug eltuing stent thrombosis. 2) To observe clinical outcomes after an episode of ST.
Primary objective: To assess the efficacy of low dose rate light fractionated aminolevulinic acid-Photodynamic Therapy (ALA-PDT) for treatment of VLS and HSIL. Clinical and histological response. Secondary objectives: Tolerence of ALA-PDT by…
Primary:- To evaluate the efficacy of the combination of temozolomide with vincristine and irinotecan in children and adult patients with relapsed rhabdomyosarcoma as assessed by confirmed objective tumor response.Secondary:- To evaluate the safety…
Primary Objective: disease related treatment failure.Secondary Objectives: Overall survival, CRM negative (margin > 1 mm) rate, Pathological complete response (pCR) rate, Short and long-term toxicity, Surgical complications, Quality of life.…
The goal of the study is to determine if the use of Hyalobarrier® Endo prevents or reduces the chance of adhesions. We also would like to know how many woman become pregnant within the year and how the pregnancy goes.
The purpose of the study is to assess the diagnostic accuracy of a combined use of non-invasive coronary angiography with multi-slice computed tomography (MSCT) and stress cardiac magnetic resonance (CMR) imaging in patients with obstructive lesions…
Our first objective is two-fold; part of it is to evaluate the suitability of the dual task paradigm as a measure for listening effort in a series of simulation experiments. We will compare a linguistic and a non linguistic secondary task in this…
Objectives:Primary:- To evaluate efficacy as measured by overall survival (OS), with a goal of demonstrating the superiority of inotuzumab ozogamicin when administered in combination with rituximab, compared with an active comparator arm.Secondary…
Arm A-Dose Escalation CohortPrimary Objectives* To describe the pharmacokinetics (PK) and safety profiles (including the maximum tolerated dose (MTD) or Optimal Biological Dose) of escalating doses of RO5429083 in patients with metastatic and/or…
Demonstrate that the usage of a quadripolar LV lead results in easier LV lead implantation procedure and less chronic LV lead related adverse events in comparison with a traditional biventricular left ventricle lead.