139 results
Primary objectives:Standard Risk R1: in a randomised trial, to examine whether add-on treatment with fenretinide or zoledronic acid, or zoledronic acid plus fenretinide in addition to induction and maintenance chemotherapy improves event-free…
The STEM study presented here aims to increase our knowledge of the most common intestinal, gastric and liver epithelial diseases with the ultimate goal to treat these disorders. Particularly, children that have severe malfunction of their…
Primary ObjectivesThe current study aims to establish the recommended dose, safety and preliminary efficacy of azacitidine administered IV or SC in children with relapsed/refractory MDS or JMML, in 2 different subgroups (strata) of patients.…
The goal of this study is to collect a large cohort of patients mainly with NSHI. In the study cohort, the genetic causes underlying the NSHI will be determined which can be either in known or novel deafness genes. Also, the clinical characteristics…
Primary:- To evaluate the efficacy of the combination of temozolomide with vincristine and irinotecan in children and adult patients with relapsed rhabdomyosarcoma as assessed by confirmed objective tumor response.Secondary:- To evaluate the safety…
PRIMAIRYThe primary objective of this trial is to evaluate the efficacy of atacicept compared to placeboin preventing new flares in subjects with SLE.SECONDARYSecondary objectives of the trial are:• To evaluate the safety and tolerability profile of…
To investigate the short-term effectiveness of a 4 month manualized home-based behavioral treatment for referred children with ADHD, aged 6 to 13 years, who have responded insufficiently to first line treatment with medication or behavioral parent…
To evaluate the efficacy, safety, tolerability, and pharmacokinetics of bevacizumab when added to postoperative radiotherapy with concomitant and adjuvant temozolomide (TMZ) and to determine whether the addition of anti-angiogenic therapy with…
Our primary objective is to investigate the development of structural and functional connectivity in autism and ADHD in comparison to the typical development of connectivity. A secondary objective is to investigate the effects of ADHD and autism…
This research aims to examine the brain regions involved in social decision making during interactions with peers and the longitudinal links between early experiences with parents and peers and social decision making in adolescence.
Primary Objective: 1) To study impairment and developmental delay in social cognition (and related cognitive functions) caused by brain damage in patients treated for a brain tumour in childhood as compared to a reference group of chronically ill…
Primary objective: To evaluate the insulin sensitivity measured with Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) in obese children and adolescents 3 years after diagnosis of insulin resistance.Secondary objectives:1. To evaluate the…
The aim of this project is to elucidate the mechanisms underlying one of the most incapacitating psychiatric disorders, psychosis. Despite antipsychotic treatment, up to a third of patients with psychotic illness continue to experience significant…
The purpose of the study is to assess the effects of CER-001, given by intravenous infusion with regards to plaque burden of the carotid arteries and the descending thoracic aorta using 3T magnetic resonance imaging (3TMRI).The objective of the…
Identification of the underlying genes of MMIHS
A randomised controlled multcenter trial is performed to evaluate the perforator-based interposition plasty in comparison to full thichness grafts for scar contracture releases.
The aim of this study is to investigate the effectiveness and the cost-effectiveness of the individual CBT program the *D(o)epressie cursus* by means of the following hypotheses;1. Is the individual CBT program the *D(o)epressie cursus* more…
- to determine possible differences in the results of the ABILHAND kids questionnaire between parent, occupational therapist and rehabilitation doctor- variance of the results in time
Primary objectives:1. To determine the effect of the use of a tailored intervention protocol (regarding reduced antimicrobial use, improving hygiene and changing the animal contact structure) on pig and veal farms on the degree of antimicrobial…
Evaluation study on the effectiveness of a new developed vaginal dilatation programme for medical-psychological treatment of vaginal hypoplasia / agenesis.