387 results
To assess microglial activation in first episode patients with psychotic symptoms and first episode medication naïve patients with psychotic symptoms compared to healthy controls using the positron emission tomography (PET) tracer [11C]-R-PK11195.
Primary Objective: What are the consequences of irradiation for the human jaw bone and oral mucosa on a macroscopic, microscopic and molecular level?Can possible prognostic factors be identified for the occurrence of peri-implantitis, dental implant…
To determine if HF subjects whose treatment is assisted by a daily BNP measurement that is integrated into a home health management system will have improved clinical outcomes versus subjects whose treatment includes home health management but is…
The main goal of this study is to recruit and obtain magnetic resonance images in a large sample of bipolar patients and controls from the Netherlands, in order to find brain abnormalities specific for bipolar disorder. We will also perform genetic…
The main aim of the present study is to improve our understanding of the role of blood-brain barrier function and cerebral perfusion in dementia of the Alzheimer*s type.
To evaluate in detail the functionality of immune cells in the liver and blood in chronic HCV patients before, during and after treatment with telaprevir, pegylated-IFN-alfa and ribavirin.
This study aims to design a nomogram for the course of serum pro-calcitonin in burn patients. For this purpose, a new, sensitive assay will be used. It is expected that the nomogram will help to differentiate between patients with a systemic…
Evaluation of the feasibility of sentinel node detection by PET-CT lymphoscintigraphy
The primary objective is to assess the vitality and process of ingrowth of autologous bone graft in PLIF during the first postoperative year in order to predict intervertebral bony union. The second objective is to assess clinical outcome measures.
To compare midazolam pharmacokinetics in morbidly obese patients before/during bariatric surgery and 0.5-2 year after surgery.
Our primary objective is to investigate the development of structural and functional connectivity in autism and ADHD in comparison to the typical development of connectivity. A secondary objective is to investigate the effects of ADHD and autism…
Primary objective:To determine the feasibility of developing predictive biomarkers by large scale DNA-sequencing for the response to irinotecan monotherapy as standard of care treatment for metastatic colorectal cancer or other solid tumors.…
Evaluation of I-FABP as diagnostic tool in mesenteric ischemia.
This study is aimed at determining pharmacokinetics and pharmacodynamics of medications routinely used at the Erasmus Medical Centre in pediatric cardiac surgery during and after cardiopulmonary bypass. The goal is to be able to formulate evidence…
2. STUDY OBJECTIVESSpecific Aim 1. To determine whether Tako-Tsubo cardiomyopathy is associated with hyper reactivity of the neurohormonal and cardiovascular systems. Hypothesis 1: Patients with a clinical history of Tako-Tsubo cardiomyopathy have…
The primary objective is to generate genome-wide miRNA profiles of patient material (tissue samples and blood). The secondary objectives are to compare miRNA expression profiles to investigate what role differences in miRNA expression have in the…
Our primary hypothesis is that the process of nasopharyngeal and fecal colonization from birth to childhood differs in quality and quantity between infants with CF and healthy controls and that these differences are related to subsequent respiratory…
1) To study the predicitve value of fear acquisition and extinction mechanisms on treatment outcome in anxiety disordered patients. 2) To study pathological fear acquisition and extinction in anxiety disorders: what are the differences in…
We will examine the activation status of platelets, the content of platelet granules, and activation of de novo synthesis of mitogenic proteins during and after a partial liver resection in patients with a malign or benign tumor including distant…
The aim of this study is to quantify residual ER binding sites during fulvestrant therapy, compared to the tracer uptake prior to fulvestrant therapy.