4437 results
To assess the efficacy, safety and cost-effectiveness of the CYP2C19 genotype guided antiplatelet treatment strategy, using clopidogrel or prasugrel/ticagrelor.
To investigate if the use of different stimulation protocols / GnRH-analogues affects embryo developmental kinetics after IVF treatment. We hypothesize that GnRH analogues differentially affect embryo development through differences in follicular…
To demonstrate that SCS is capable of treating otherwise refractory neuropathic pain after chemotherapy / radiotherapy.
The goal of this research project is to evaluate effectiveness of a cognitive behavioural therapy self-help intervention offered through the Internet in multiple sclerosis (MS) patients with a co-morbid depressive symptoms. With the online guided…
In this study we will investigate the management of HCA during pregnancy based on a prospectively acquired online database in the Netherlands.
To find out if MEK162 is safe and what effects (good of bad) it has on the patient.. To understand what MEK162 does in the patient and assess what the patient does to clear the studymedication from the system. And last but not least to find out what…
The major objective is to investigate the effects of the GR polymorphisms on metabolism in the skeletal muscle, in order to unravel the pathophysiological mechanisms underlying previously observed clinical effects in carriers of this polymorphisms.…
The International GBS Outcome Study (IGOS) aims to identify the most important clinical and biological determinants of disease progression and recovery in GBS. This information will be used to understand the diversity in clinical presentation and…
The objective of this study is to improve the understanding of subjective cognitive complaints expressed by patients with OSAS by:1. Comparing subjective cognitive complaints of patients with OSAS to healthy controls2. Studying the effect of…
The goal of the trial is to compare the efficacy and costs of bevacizumab 1.25 mg and ranibizumab 0.5mg given as monthly intravitreal injections over 6 months for the treatment of macular edema secondary to a retinal vein occlusion.
In this prospective observational cohort study we aim to study the potential clinical consequences of antibiotic use in early life, by focussing on the incidence of eczema, as well as food allergy, upper respiratory tract infections (URTI), lower…
The study is primarily designed to compare the clinical outcome between the TM transfer and the LD transfer in patients with a massive posterosuperior rotator cuff tear. Our secondary objective is to asses the quality of life in patients undergoing…
This study aims to compare two management strategies by an international randomized controlled trial: the first relies on the overall conclusion from the Eurofoetus trial and advocates immediate percutaneous fetoscopic surgery for all stages of TTTS…
In this study the best treatment of DSPS will be investigated by comparison of existing treatments. We will investigate is patients with ADHD and DSPS have less favorable blood values for biomarkers of chronic diseases in comparison with norm values…
To evaluate whether SAH patients treated by state-of-the-art SAH management with additional ultra-early and short term TXA administration have a significantly higher percentage of favourable outcome after six months (score 0-3 on the Modified Rankin…
It is required to compare results from conservative- and surgical treatment in The Netherlands and to perform an economic evaluation in order to evaluate the cost-effectivity of both treatment types. On one hand, surgical treatment seems accompanied…
The current study aims to evaluate magnetic resonance imaging (MRI)-based CVR measurements with ACZ in SCD. It*s primary objective is to assess whether there is a correlation between CVR with silent cerebral infarcts (SCI) (i.e. the cerebrovascular…
The primary objective is, in patients at low-density lipoprotein cholesterol (LDL-C) goal while on statin therapy, with established cardiovascular disease (CVD) or at high risk for CVD, and hypertriglyceridemia (fasting triglycerides [TG] *200 mg/dL…
Objectives: The primary objectives of the study are to assess whether 80 mg LY2439821 every 2 weeks (Q2W) or every 4 weeks (Q4W) is:* Superior to placebo at Week 12 in the treatment of patients with moderate-to-severe plaque Ps as measured by: o…
Primary: superiority of dabrafenib and trametinib combination therapy over vemurafenib monotherapy with respect to overall survival for subjects with advanced/metastatic BRAF V600E/K mutation-positive cutaneous melanoma.Secondary: progression free…