2177 results
Primary Objective: To prove the hypothesis that Intradiscal Methylene blue is capable of longer pain reduction and better global perceived effect in patients suffering from chronic axial low back pain from discogenic origin then a placebo treatment…
To investigate the relation of platelet responsiveness and systemic platelet activity to phenotype in patients with severe hemophilia A.
The objective of this study is to prove that the number of oocytes and the quality of embryos obtained from these oocytes harvested with this new needle is comparable with the number of oocytes and quality of embryos obtained from oocytes harvested…
Before a countermeasure or training can be developed to counteract physical deconditioning it is important to investigate more in detail the magnitude and time course of physical deconditioning and to investigate which outcome measure is most…
Calculating the incidence of atherosclerosis in patients undergoing a CT-scan of the abdomen for other reasons. Calculating incidence of untreated risk factors for CVD in patients with atherosclerosis on the CT-scan.
The aim of this study is to determine whether nose potential difference response is impaired in patients with FIC1-deficiency.
*To assess the efficacy of VMP versus high-dose therapy (HDT) and stem cell transplantation in patients with previously untreated multiple myeloma, as measured by the progression free survival.**To evaluate the effect of consolidation with VRD…
* To investigate the long-term safety and tolerability of ponesimod * To investigate the long-term efficacy of ponesimod* To explore the dose response relationship of 10, 20 and 40 mg ponesimod on lymphocyte count, MRI endpoints and annualized…
We want to study whether consumption of Lactobacillus acidophilus NCFM* can improve the resistance of humans to intestinal ETEC infection. An important parameter of intestinal resistance is the so-called colonization resistance. The colonization…
Main objectives: (1) To identify genetic, environmental and clinical determinants of psychosis vulnerability and onset. (2) To assess neural systems and behavioural substrates mediating gene environment interactions. (3) To test for gene-…
Primary objective:• To determine the maximum tolerated dose of radiation to the FDG-PET avid subvolume within the GTV of the primary tumor. Secondary objectives:• To determine the incidence and severity of acute and late toxicity of dose escalation…
Primary objectiveTo compare the wear rate 60 months after THA of HXLPE stabilized with vitamin E versus conventional UHMWPE for total joint arthroplasty. Secondary objectives- To compare the wear rate at 3,12, 24 and 60 months after THA between…
Main objective:Have formerly preeclamptic women, 5 to 10 years post-partum, a higher prevalence of a cardiovascular riskprofile compared to women with uncomplicated pregancies in history.
Primary objectiveTo determine the maximum tolerated dose (MTD) and characterize the dose-limiting toxicities (DLT) of LEQ506 when administered orally on a continuous daily dosing schedule.Secondary objectives* To characterize the safety and…
In this trial we will compare two ways of suturing the ileostomy, intracutaneous sutures or transcutaneous sutures (hence the acronym ISI-trial; Intracutaneously Stitched Ileostomy trial). There is no consensus about which technique should be used.…
Primary- MRI: correlation between neovascularisation in carotid atherosclerotic plaque characteristics assessed by dynamic 3.0 Tesla MRI and carotid atherosclerotic plaque at histology. - CT: correlation between size of lipid-rich-necrotic-core in…
Primary objective:To demonstrate that the mean change from baseline in Best Corrected Visual Acuity (BCVA) over a 12 month treatment period obtained with either a 0.5 mg ranibizumab *Treat and Extend* (TE) dosing regimen with adjunctive laser, and/…