4382 results
To assess the efficacy, safety and cost-effectiveness of the CYP2C19 genotype guided antiplatelet treatment strategy, using clopidogrel or prasugrel/ticagrelor.
To demonstrate that SCS is capable of treating otherwise refractory neuropathic pain after chemotherapy / radiotherapy.
The goal of this research project is to evaluate effectiveness of a cognitive behavioural therapy self-help intervention offered through the Internet in multiple sclerosis (MS) patients with a co-morbid depressive symptoms. With the online guided…
In this study we will investigate the management of HCA during pregnancy based on a prospectively acquired online database in the Netherlands.
To find out if MEK162 is safe and what effects (good of bad) it has on the patient.. To understand what MEK162 does in the patient and assess what the patient does to clear the studymedication from the system. And last but not least to find out what…
To study the feasibility of reducing the dose of preoperative radiotherapy in MLS from 50Gy to 36Gy while maintaining comparable clinicopathological responses.
The goal of the trial is to compare the efficacy and costs of bevacizumab 1.25 mg and ranibizumab 0.5mg given as monthly intravitreal injections over 6 months for the treatment of macular edema secondary to a retinal vein occlusion.
In this prospective observational cohort study we aim to study the potential clinical consequences of antibiotic use in early life, by focussing on the incidence of eczema, as well as food allergy, upper respiratory tract infections (URTI), lower…
Primary: To demonstrate that high (100%) stimulation of ONS therapy reduces the mean attack frequency (MAF) in MICCH by at least 35% compared to low (30%) stimulation of ONS.Secondary: To evaluate • the rate of responders (>= 50% reduction in…
To prove that the NANOS prosthesis is a good prosthesis to be used in total hip replacement surgery, with low revision rate (< 10%) after 10 years. This percentage is known in the Swedish registry.Second objective is to prove that clinical…
With this research we aim at gaining more insight into the reason for the fact that some individuals reconstitute well during cART whereas other do not. Also, we would like to investigate what mechanism is responsible for reconstituting the CD4 T-…
To assess the feasibility and efficacy of Carfilzomib in combination with Thalidomide and Dexamethasone in a phase II trial.
To predict and evaluate the effectively and safety of ECT in depressed elderly.1. the relation between clinical parameters and the safety and effectively of ECT in elderly with a severe depressive disorder2. the relation between structural brain…
Primary objectives:Standard Risk R1: in a randomised trial, to examine whether add-on treatment with fenretinide or zoledronic acid, or zoledronic acid plus fenretinide in addition to induction and maintenance chemotherapy improves event-free…
Primary Objective: To prove the hypothesis that Intradiscal Methylene blue is capable of longer pain reduction and better global perceived effect in patients suffering from chronic axial low back pain from discogenic origin then a placebo treatment…
The STEM study presented here aims to increase our knowledge of the most common intestinal, gastric and liver epithelial diseases with the ultimate goal to treat these disorders. Particularly, children that have severe malfunction of their…
The objective of the study is to investigate the feasibility and efficacy of treatment with lenalidomide and rituximab with or without bendamustine in patients with relapsed follicular lymphoma.
Primary ObjectivesThe current study aims to establish the recommended dose, safety and preliminary efficacy of azacitidine administered IV or SC in children with relapsed/refractory MDS or JMML, in 2 different subgroups (strata) of patients.…
The aim of the trial is to individualize treatment for each patient by adapting it to early response and to treat only those patients with addiotional radiotherapy who show an inadequate treatment response. The degree of treatment response is…
The goal of this study is to collect a large cohort of patients mainly with NSHI. In the study cohort, the genetic causes underlying the NSHI will be determined which can be either in known or novel deafness genes. Also, the clinical characteristics…