1979 results
The principal and primary research questions are:Primary objective: 1) What are the differences in clinical myocardial infarction (heart attack) rates and in stroke and death within 30 days of carotid stenting compared with carotid endarterectomy?…
The main objective of this study is to estimate the rate of response to dasatinib in children and adolescents with certain types of Ph+ leukaemia either whose disease is resistant to, intolerant to or relapsed after previous imatinib therapy or are…
To determine whether a second IVIg course in GBS patients with a poor prognosis improves functional outcome after 4 weeks.
We hypothesize that intracranial vessel wall atheromas are an important underlying cause of obstruction of (one of the) artery(ies) of the anterior cerebral circulation. To test our hypothesis we will perform high resolution intracranial vessel wall…
In view of this lack of evidence and strong practice variation we propose a randomized clinical trial in overweight and obese subfertile women, in which we compare the costs and effects of a six months structured lifestyle program, aimed at weight…
The primary objective of this study is to assess presence, number, type, specificity and function of HPV-specific immune response in the peripheral blood, lesions/tumors and their draining lymph nodes of patients at different stages of HPV-induced…
Establish the non-inferiority of the R3 acetabular system with a high survival rate at 10 years fu (at least 90%). Second objective is to establish good clinical results by means of (Harris Hip Score, Hoos, UCLA and radiologic failures (like…
The purpose of this study is to determine the safety and efficacy of post-surgery treatment with the monoclonal antibody ipilimumab, to see whether treatment improves recurrence-free survival (RFS), overall survival and distant metastases-free…
The aim of the trial is to individualize treatment for each patient by adapting it to early response and thus to continue intensive treatment only with those patients wo show an inadequate treatment response.For patients who show a good initial…
The primary objective of this study is to determine whether daily oral supplementation of Vitamin K2 will slow down or arrest CAC-progression after 12 and 24 months in comparison to placebo in patients with established CAC. Secondary, we wish to…
To assess the short term and medium term weight loss after bariatric surgery compared to conservative therapy, to determine the prevalence and the effect of weight loss on obesity associated morbidity in adolescence, to measure the effect of…
The objective of this study is to collect basic function and patient satisfaction datafor observation and analysis.Specific objectives include the following:Evaluate the effect of component design on functional performance by comparing…
The Biobank 'Leukemia, Myeloma, Lymphoma and Myelofibrosis' has the scientific objective of gaining insight in molecular-biological and environmental factors, that are involved in the development of malignant hematological diseases such as…
Objectives: - to increase the proportion of patients with non-severe GVHD within 180 days post-allo-SCT - to reduce the progression rate - to improve the progression free survival- to asses the impact on the quality of life using a time restricted…
The objective is to describe differences in MRI patterns in presymptomatic mutation carriers, patients with mild dementia and controls. We will study whether these patterns are specific depending on the type of dementia (FTD/AD) or mutation (GRN/…
The primary objective is to investigate brain functioning during fear conditioning and reward/punishment conditions in relation to persistent and desistent DBD patterns by means of functional magnetic resonance imaging (fMRI), in a large cohort of…
Aim of the present study is to set up a large cohort of IBS patients in order to identify different disease characteristics as well as aetiological and pathophysiological factors in (sub)groups of patients with this heterogeneous disorder. Various…
The aim of the current study is to identify how increased genetic risk for developing a psychotic disorder affects brain development by studying neurobiological and neuropsychological, clinical an environmental markers in first and second degree…
This phase II/III controlled multicenter trial will investigate the ability of individualized chemotherapy to improve the objective response rate of *triple-negative* breast cancer (estrogen receptor and progesterone receptor-negative, no HER2…