415 results
Primary objective:To evaluate efficacy of RO5185426 as a monotherapy compared to dacarbazine in terms of progression-free survival (PFS) and overall survival (OS) in previously untreated patients with advanced melanoma harbouring the BRAF V600E…
Our proposed randomized controlled trial is the first making this head-to-head comparison in a *real life* primary care setting in the Netherlands. The primary research question is: does a 12-week combination therapy of open label varenicline and…
PrimaryTo investigate sensitivity and specificity of 3.0 Tesla MRI and MRS for dimension and composition assessment of carotid artery plaques, in particularly those plaques with lipid rich necrotic cores (LRNC), with the aim to develop these…
Primary Objectives * To assess the efficacy of rosuvastatin in paediatric patients with familial hypercholesterolaemia. * To establish long-term safety, tolerability and efficacy of rosuvastatin in paediatric patients with familial…
This study is designed as an extension study to the proof-of-concept trial CAIN457A2209 in patients with ankylosing spondylitis and aims to provide continuous treatment with AIN457 for patients in the core trial, to obtain safety and tolerability…
The purpose of the study is to evaluate the safety and effectiveness of the LINX device in the treatment of GERD
To investigate the influence of left and right lateral position on the onset of TLESRs and GER and the underlying mechanisms during and after a test meal in GERD patients compared to healthy controls.
The present study aims at testing whether the 0.07% CPC-mouthrinse has a potential to inhibit gingival inflammation as compared to a placebo over a 6 month period.
Primary objective* To evaluate ocular and non-ocular adverse events during the 24-months study period in patients treated with Lucentis (0.5 mg)Secondary objectives* To describe the ocular and non-ocular adverse events over a cumulative 36-months…
The objective of the study is to standardize portal placement in endoscopic calcaneoplasty, thereby taken into account the three different foot shapes, cavus, valgus and normal feet. Primarily the FOPP- device needs to be validated. If found valid,…
The main objective is to find the neural correlates of route choice with an event-related fMRI experiment.
To sess the relationship between cerebral perfusion and clinical findings (neurological and neuropsychological) in patients with sickle cell disease.To compare iamging fincdings in children with and without sickle cell disease.
In patients with BO undergoing surveillance or work-up endoscopy for early neoplasia, we aim to evaluate if EQMI, consisting of ETMI combined with pCLE, increases the accurary of detecting early neoplasia (study phase 1). In addition, we aim to…
The purpose of the present study is to examine the perception of immigrant parents of their child*s beta thalassemia and the provided care during treatment with stem cell transplantation in the Netherlands. It is important to study and learn about…
The main objective of the single center, observational study is to assess the immediate and long term effects of PAVI on LVF and coronary flow by means of pressure volume loops, intracoronary flow assessment, echocardiography and cardiac MRI/CT.…
Our experiment has two objectives. First, it is designed to determine whether cross-modal classification is possible, and so resolve the different conclusions reached in Etzel, Gazzola et al. (2008) and Dinstein, Gardner et al. (2008). Second, the…
OBJECTIVES: -to assess the usefulness of DA-phMRI (task related fMRI, steady state fMRI and ASL based phMRI) in assessing amphetamine induced DA-neurotoxicity when compared to DAT SPECT.-to assess which MRI technique (task related fMRI, steady state…
To test an intra-operative fluorescent camera system with a fluorescent optical agent in detection of the sentinel lymph node. This will be compared to the standard method with radiocolloid and patent blue.
This study aims to show by which technique the patient feels the least pain. It is also designed to show which advantages and disadvantages are linked to the abovementioned forms of anesthesia and if there are differences in postoperative pain…
The primary objective is to study the effects of GH substitution therapy in adult GH deficient survivors of childhood cancer. Primary endpoints are organ size, renal function and capillary density of the skin.