136 results
- To determine physical fitness in children with a congenital heart disease (ventricular septum defect, atrium septum defect, tetralogy of Fallot, transposition of large arteries and patients after a (modified) Fontan-operation) and to compare…
the aim of the study is to assess whether short lived limited increases in airway pressure are sufficient to combat ET suction induced hypoxemia
Identifying subsets of Crohn's disease (CD) at risk for poor outcomes is a priority in pediatric CD research. Having the ability to predict patients more likely to relapse, to be refractory to therapy or to develop complications may enable…
The primary objective of this study is to assess the comparative safety and efficacy ofAztreonam Lysine for Inhalation (AZLI) and Tobramycin Nebuliser Solution (TNS) in adultand pediatric cystic fibrosis (CF) patients aged 6 years or older with…
The objectives of this open-label study are to evaluate the efficacy (GL-3 clearance), pharmacokinetics (PK), and safety parameters (including immunogenicity) for 2 alternative dose regimens of Fabrazyme (0.5 mg/kg every 2 weeks [q2w] and 1.0 mg/kg…
Primary:- Can carboplatin exposure in children be predicted by taking the plasma concentrations of creatinine of cystatine C into account?Secundary:- Which is the effective carboplatin exposure in the current pediatric treatment protocols?- Is there…
1- to describe the presence and severity of hemiplegic CP on the basis of neonatal MRI findings and correlate the involvement of different structures (basal ganglia, posterior limb of the internal capsule and hemisphere) with the size of the lesion2…
The overall aim of the project is to define effects of genetic and non-genetic variants on pharmacological treatment response in children with asthma. The following questions will be answered:- What are the characteristics of children who do not…
To test the hypothesis that IVIG treatment diminish the risk of development of chronic disease, we designed a prospective clinical intervention study in children with newly diagnosed ITP.
Primary Objective: (diagnostic)• Does MRI detect structural changes of haemophilic arthropathy in knees and ankles undetected by the Pettersson score and HJHS? (Research question 1 a & b)Secondary Objective(s): (prognostic)• Can MRI predict…
The assessment of the duration of the cellular immunity to Bordetella pertussis after an extra ACV booster and the relationship between the memory B- cells and antibody responses. The methods used in the study are:B- and T- cell memory responses and…
Primary: To provide insight in the prevalence of diagnosed cases of IgG-subclass and/or antipolysaccharide antibodydeficiency in Dutch children. Secondary: To provide insight in the diagnostic process, the clinical presentation, the therapies used…
1 To determine the phenotype and biological characteristics of mesenchymal stem cells derived from pediatric MDS patients as determined by flow cytometric analysis, cell culture and differentiation abilities analyzed by subtype of MDS compared to de…
Primary objective: to determine the effect of Mindful MirrorExposure in the treatment of eating disordered patients.
To assess in a cohort of patients with established FAP:1 The efficacy of MPA in terms of reduction of number of colonic polyps, by means of Endoscopic Appearance of Polyposis (EAP) index.2 The effect on histological parameters and biological…
This project aims to examine the implementation and effectiveness of MST in The Netherlands.The aim of Implementation study is to determine the degree to which MST is implemented as intended at different sites in The Netherlands. Following questions…
To conduct a randomised trial to test the hypothesis that the experimental condition, i.e. the intervention*Gezin aan bod*, is superior to 'care-as-usual' in exerting a positive effect on a number of the risk factorsfor problematic…
Heart rate variability in obese adolescents in relation to insulin levels during OGTT.
A pilot study
The aim of the project is to study the relation between hyperinsulinemia and changes in autonomic tone in adolescents with obesity. We have chosen to perform a pilot study, because of lack of comparable studies in the literature.
The objective of this study is to determine whether the dichotomization in good and poor outcome by the composite scale, corresponds better with the parents' and doctor's opinion on the outcome than the PSOM. The composite scale willl be…
To determine if home spirometry (FEV1) predicts pulmonary exacerbation of CF before symptoms appear.