157 results
- To determine physical fitness in children with a congenital heart disease (ventricular septum defect, atrium septum defect, tetralogy of Fallot, transposition of large arteries and patients after a (modified) Fontan-operation) and to compare…
the aim of the study is to assess whether short lived limited increases in airway pressure are sufficient to combat ET suction induced hypoxemia
Identifying subsets of Crohn's disease (CD) at risk for poor outcomes is a priority in pediatric CD research. Having the ability to predict patients more likely to relapse, to be refractory to therapy or to develop complications may enable…
The primary objective of this study is to assess the comparative safety and efficacy ofAztreonam Lysine for Inhalation (AZLI) and Tobramycin Nebuliser Solution (TNS) in adultand pediatric cystic fibrosis (CF) patients aged 6 years or older with…
The research question of the main study is: What are the short- and long-term effects and costs of helmet treatmentcompared to a wait-and-see regimen for a period of 6 months on skull asymmetry in children withmoderate to severe DP.The objective of…
The objectives of this open-label study are to evaluate the efficacy (GL-3 clearance), pharmacokinetics (PK), and safety parameters (including immunogenicity) for 2 alternative dose regimens of Fabrazyme (0.5 mg/kg every 2 weeks [q2w] and 1.0 mg/kg…
Primary:- Can carboplatin exposure in children be predicted by taking the plasma concentrations of creatinine of cystatine C into account?Secundary:- Which is the effective carboplatin exposure in the current pediatric treatment protocols?- Is there…
The project aims to gain more insight in the process of bonding between parents and prenature infants, to validate a screening instrument that can be easily adopted in maternity wards of (general) hospitals to detect parents and children at risk for…
Primary objective: -to determine if there is a significant difference in the incidence of oxygen dependency at day 28 and/or death within the first 28 days of life between newborns with congenital diaphragmatic hernia treated with high frequency…
The purpose of this study is to show no difference in the outcome with abduction treatment versus no treatment in stable hip dysplasia between the age of 3 and 6 months.
To establish the effect of BCG vaccination in 6 weeks old high-risk infants on the prevalence of asthma and allergic rhinitis at the age of 7 years.
1- to describe the presence and severity of hemiplegic CP on the basis of neonatal MRI findings and correlate the involvement of different structures (basal ganglia, posterior limb of the internal capsule and hemisphere) with the size of the lesion2…
The overall aim of the project is to define effects of genetic and non-genetic variants on pharmacological treatment response in children with asthma. The following questions will be answered:- What are the characteristics of children who do not…
1. To identify and specify bacteria by using RT-PCR on blood and cerebrospinal fluid (CSF) in preterm infants, having nosocomial sepsis and meningitis.2. To compare RT-PCR (see aim 1) with the gold standard bacterial culture in preterm infants,…
To test the hypothesis that IVIG treatment diminish the risk of development of chronic disease, we designed a prospective clinical intervention study in children with newly diagnosed ITP.
The assessment of the duration of the cellular immunity to Bordetella pertussis after an extra ACV booster and the relationship between the memory B- cells and antibody responses. The methods used in the study are:B- and T- cell memory responses and…
The purpose of the project is a) to examine evidence-based instruments (DFSI, ASQ:(SE) and ITSEA) in the Netherlands in practices of midwives and within the system of health care and b) to gain more insight into the role of specific risk- and…
Primary: To provide insight in the prevalence of diagnosed cases of IgG-subclass and/or antipolysaccharide antibodydeficiency in Dutch children. Secondary: To provide insight in the diagnostic process, the clinical presentation, the therapies used…
1 To determine the phenotype and biological characteristics of mesenchymal stem cells derived from pediatric MDS patients as determined by flow cytometric analysis, cell culture and differentiation abilities analyzed by subtype of MDS compared to de…
To assess whether TW and PW show differences in number, phenotype or function of regulatory T-cells in peripheral blood samples. Details on study determinants will be based on the outcome of the pilotstudy (Regulatory T cells in asthma; PREDART0807…