553 results
To identify (low-grade) inflammatory signs in patients with symptomatic hand OA using ultrasound. Secundary to investigate whether clinical symptoms such as pain and disability, and radiological status correlate with (low0grade) inflammation and…
- To determine physical fitness in children with a congenital heart disease (ventricular septum defect, atrium septum defect, tetralogy of Fallot, transposition of large arteries and patients after a (modified) Fontan-operation) and to compare…
the aim of the study is to assess whether short lived limited increases in airway pressure are sufficient to combat ET suction induced hypoxemia
The primary objective is to determine if intra-articular etanercept therapy reduces the clinical signs and symptoms of inflammatory arthritis and improve outcome (beneficial effect). The secondary objective is to study safety and to analyse…
The study will assess the hypothesis that the combination warfarin & clopidogrel 75 mg/day is superior to triple therapy (warfarin + clopidogrel 75mg/day + aspirin 80mg/day) with respect to bleeding complications while equally safe with…
The primary objective is to determine the efficacy (as measured by pulmonaryfunction) and safety of CNTO 888 in subjects with IPF. The major secondary objectives are to assess theeffect of CNTO 888 on measures of disease progression, to assess the…
Primary:To determine the response rate and response quality of dasatinib monotherapy or dasatinib/fludarabine combination in fludarabine refractory CLL patientsSecundaryTo asses the overall safety profile of this treatment approachTo asses event…
The project aims to gain more insight in the process of bonding between parents and prenature infants, to validate a screening instrument that can be easily adopted in maternity wards of (general) hospitals to detect parents and children at risk for…
The purpose of this study is to determine the need for thromboprofylaxis in patients being treated in a below-knee plaster cast after trauma of a lower extremity and if there is, to assess if both of the two tested prophylactic treatments are suited…
To investigate prospectively how the "TAMRO-profile" performs in a pre-operative treatment setting. In addition we can examine whether the profile is specific for tamoxifen or is predictive for endocrine resistance in general. Also the…
To assess the effect of low dose doxycycline on markers of neutrophilic inflammation and proteolytic activity stable GOLD III COPD patients.
To assess in a cohort of patients with established FAP:1 The efficacy of MPA in terms of reduction of number of colonic polyps, by means of Endoscopic Appearance of Polyposis (EAP) index.2 The effect on histological parameters and biological…
The primary objective is to investigate whether insulin sensitivity can be preserved postoperatively, by giving a simple carbohydrate-rich drink before surgery. Furthermore, to investigate whether gastric passage will be enhanced postoperatively…
Primary Research Question:Is the disease activity halfway through the infusion significant higher compared to the disease activity at the start if infusion or lower compared to the disease activity at the end of infusion?Secundary Research Questions…
To assess whether internet-based telemonitoring of pulmonary function at home can prevent severe pulmonary exacerbations and lead to a reduction of hospital admission in patients with CF.
To test the hypothesis that oral parafunctioning, viz. prolonged gum chewing, has an effect upon the functional symptoms of internal derangements of the temporomandibular joint. To test the hypothesis that the effect of the above-mentioned oral…
To assess the influence of external pressure on the os pisiforme on carpal movements in patients with midcarpal instability
To determin the effect of low dose azithromycin ( 3 times a week 250 mg) on the cough related health status in patients with COPD and chronic productive cough.In a randomized controlled study.
Heart rate variability in obese adolescents in relation to insulin levels during OGTT.
A pilot study
The aim of the project is to study the relation between hyperinsulinemia and changes in autonomic tone in adolescents with obesity. We have chosen to perform a pilot study, because of lack of comparable studies in the literature.
Objectives1. to determine whether nebulization of heparin decreases coagulation activation in the pulmonary compartment (i.e. BAL fluid)2. to determine whether nebulization of heparin decreases pulmonary vascular permeability