368 results
Are there differences is efficacy, side effects, tolerance en costs in patients with early RA in treatment with COBRA-light compared with COBRA according to BeSt?
5. Study objective(s) and hypothesis:The aim of this study is to assess the value of early, intensive and efficient treatment of patients with recent acquired arthritis, in preventing progression into destructive RA
To compare accuracy, patient experience and costs of lower gastrointestinal endoscopy (sigmoidoscopy and colonoscopy) between nurse and physician endoscopists.
To validate that OTR4120 will improve the healing of chronic ulcers.
Development, optimization and implementation of retro-orbital fibroblast cultures in our laboratory.
The primary objective of this study is to identify mutations associated with the development of a bicuspid aortic valve. To this end the study will focus on genes important for aortic valve formation. As an extension of the primary objective, a…
To evaluate the efficacy of ROLL versus WGL in breast conserving surgery for non-palpable breast cancer.
The main objective of the study is a head tot head comparison of the everolimus coated XIENCE-V* stent with the paclitaxel coated TAXUS* stent in order to observe whether there is a difference in clinical outcome between both stents. Efficacy of…
The study is divided in two parts. In the first part, we will study our hypothesis that the biological activity of antiangiogenic therapy is partly mediated by inhibition of platelets. We will study whether antiangiogenic agents inhibit the…
the objective of the current study is to evaluate the safety and efficacy of enzyme therapy in the Dutch population of patients with MPS I, II and VI; to compare this to the natural course of these diseases; to make an inventory of the direct and…
The objective of the study is to improve quality of life of patients with Hepatitis C, by teaching patients psychological skills that aid in coping with the consequences of the disease.
The objective of this study is to to develop a selective and non-selective whole brain ASL perfusion stress test and at 3.0 Tesla based on ASL flow territory measurements.
The main objective of this project is to study the relationship between dopaminergic mechanisms and apathy in dementia. The related question, both theoretically and of direct relevance for daily practice, is whether patients with dementia are…
To investigate whether patients with schizophrenia show reliable and consistent brain activations as measured with fMRI to two different stimulation paradigms and wether they differ in terms of the patterns or the intensity of activation as compared…
The aim of the study is to evaluate the cost-effectiveness of a personal health portal on internet to promote physical activity and fruit and vegetables consumption among workers. The specific research questions are:1. Does the personal health…
The goal of this study will be to determine a functional benefit and an increase in patient satisfaction after a period of one year of open reduction and internal fixation (ORIF) by volar approach versus percutaneous reposition and fixation with…
The primary objectives of the study are:- to establish the optimal dose of the combination for second-line therapy with NAMI-A and Gemcitabine (Phase I part)- to assess the response rate according to RECIST criteria (Phase II part) in advanced NSCLC…
To determine whether the T1405N SNP in the CPS-1 gene is associated with lower plasma L-arginine concentrations in preterm infants and to determine whether the T1405N SNP in the CPS-1 gene is associated with a higher risk of NEC.
The main objective is to investigate if the use of 5mm needles has a positive effect concerning hypoglycemic events and local complaints like bruising, bleeding, back flow of insulin and pain compared to 8mm needles, and to receive information about…
To evaluate the diagnostic effectiveness of MSCT in making a distinction between ischemic and non-ischemic cardiomyopathy in symptomatic patients. If MSCT proves to be a reliable diagnostic, ICA can be reserved for therapeutic purposes only. This…