3831 results
To evaluate the efficacy ofa. early intensification of rituximab combined with 2-weekly CHOP+G-CSF (R-CHOP14) in remission induction treatment in comparison to standard R-CHOP14b. maintenance treatment with rituximab in patients in remission after R…
To investigate if the use of different stimulation protocols / GnRH-analogues affects embryo developmental kinetics after IVF treatment. We hypothesize that GnRH analogues differentially affect embryo development through differences in follicular…
To establish one large overarching cohort including all types of SpA (both non-radiographic, radiographic axial SpA and peripheral SpA) regardless of the disease stage and treatment and to longitudinally asses several disease aspects of SpA. The…
The major objective is to investigate the effects of the GR polymorphisms on metabolism in the skeletal muscle, in order to unravel the pathophysiological mechanisms underlying previously observed clinical effects in carriers of this polymorphisms.…
The International GBS Outcome Study (IGOS) aims to identify the most important clinical and biological determinants of disease progression and recovery in GBS. This information will be used to understand the diversity in clinical presentation and…
The objective of this study is to improve the understanding of subjective cognitive complaints expressed by patients with OSAS by:1. Comparing subjective cognitive complaints of patients with OSAS to healthy controls2. Studying the effect of…
The study is primarily designed to compare the clinical outcome between the TM transfer and the LD transfer in patients with a massive posterosuperior rotator cuff tear. Our secondary objective is to asses the quality of life in patients undergoing…
This study aims to compare two management strategies by an international randomized controlled trial: the first relies on the overall conclusion from the Eurofoetus trial and advocates immediate percutaneous fetoscopic surgery for all stages of TTTS…
In this study the best treatment of DSPS will be investigated by comparison of existing treatments. We will investigate is patients with ADHD and DSPS have less favorable blood values for biomarkers of chronic diseases in comparison with norm values…
To evaluate whether SAH patients treated by state-of-the-art SAH management with additional ultra-early and short term TXA administration have a significantly higher percentage of favourable outcome after six months (score 0-3 on the Modified Rankin…
It is required to compare results from conservative- and surgical treatment in The Netherlands and to perform an economic evaluation in order to evaluate the cost-effectivity of both treatment types. On one hand, surgical treatment seems accompanied…
The current study aims to evaluate magnetic resonance imaging (MRI)-based CVR measurements with ACZ in SCD. It*s primary objective is to assess whether there is a correlation between CVR with silent cerebral infarcts (SCI) (i.e. the cerebrovascular…
The primary objective is, in patients at low-density lipoprotein cholesterol (LDL-C) goal while on statin therapy, with established cardiovascular disease (CVD) or at high risk for CVD, and hypertriglyceridemia (fasting triglycerides [TG] *200 mg/dL…
Objectives: The primary objectives of the study are to assess whether 80 mg LY2439821 every 2 weeks (Q2W) or every 4 weeks (Q4W) is:* Superior to placebo at Week 12 in the treatment of patients with moderate-to-severe plaque Ps as measured by: o…
Primary: superiority of dabrafenib and trametinib combination therapy over vemurafenib monotherapy with respect to overall survival for subjects with advanced/metastatic BRAF V600E/K mutation-positive cutaneous melanoma.Secondary: progression free…
To evaluate the cost-effectiveness of the Demands and Capacities Model based treatment (Dutch standard) compared to the Lidcombe programme for early stuttering intervention.Follow-up: Long-term outcome, taking into account recent genetic findings.
Main Objective: To assess the effects of OCA in patients with PBC on: -Serum alkaline phosphatase (ALP) and total bilirubin, together as a composite endpoint -SafetySecondary Objectives:To assess the effects of OCA in patients with PBC on:-…
Objective: The main objective of this study is to explore the executive, social-cognitive, and social functioning and behaviour of HT1 patients in relation to present and past tyrosine and phenylalanine levels, history of treatment and treatment…
The NECTAR-HF feasibility trial is designed to evaluate the application of right vagal nerve stimulation, also referred to as NeuroCardiac Therapy (NCT), in heart failure patients with a New York Heart Association Class II or III, an ejection…
The primary aim of this study is to gain knowledge on the natural course of Dupuytren's disease, in adults with various Dupuytren disease stages. Secondary aims are: - Gain insight in course after treatment- Determine whether there are risk…