969 results
1) To assess whether galactosemia women with ovarian failure are able to produce estradiol after exogenous (normally bioactive) FSH and LH gift 2) To characterize FSH glycan structures
In previous studies we have identified specific receptor and surface protein expression profiles on neutrophils. Some of these profiles point at partially refractory neutrophils. In the current NERTHUS study we have seen that circulating neutrophils…
Evaluation of the capacity of a HPV 16 peptide vaccine to install a long term HPV-specific T cell response, to define the importance of a booster vaccine after 1 year, the induction of Cytotoxic T lymphocyte (CTL) immunity against HPV16E6 and E7 and…
With a standardized approach in a population with difficult to treat hypertension we want to explore how frequenty PHA is a cause of hypertension and what the test characteristics of the aldosterone-renin ratio are. Additionally we want to…
To evaluate the effect of KW-3902IV in addition to IV loop diuretic therapy on heart failure signs and symptoms, persistent renal dysfunction, morbidity and mortality, and safety in subjects hospitalized with acute heart failure syndrome, volume…
This study is carried out to assess the effectiveness of rectal balloon training (RBT)combined with pelvic floor muscle training (PFMT) compared to pelvic floor muscle training alone in a population of patients with FI.
The purpose of this study is to show that participation in an exercise programme will increase the exercise tolerance, musle power and health-related quality of life and will diminish the degree of fatigue in children on dialysis.
Impact of introduction of real-time viral PCR on clinical decision making and costs in children with a respiratory tract infection.
The two objectives of our proposal are: (i) to identify specific gene expression profiles in blood and fibroblasts from patients with ALS or ALS-mimic in order to improve diagnosis and measure disease progression; (ii) the identification of genetic…
The objective of this study is to investigate the evolution of the 18F-deoxyglucose (FDG) uptake and the tumour characteristics determined in the plasma of patients with lung cancer during and after concurrent radiotherapy and chemotherapy.
The objective of this phase III study is to compare the efficacy of sorafenib in combination with gemcitabine and cisplatin versus placebo with gemcitabine and cisplatin for first-line treatment of patients with stage IIIB (with effusion) or Stage…
To compare the clinical efficacy of 500 mg MBP8298 given intravenously every six months for a period of two years, to placebo, in subjects diagnosed with SPMS who are positive for the HLA DR2 and/or DR4 haplotype. Clinical efficacy is defined as a…
The purpose of the study is to assess the quantitative accuracy of the experimental HRRT PET scanner and to assess the potential benefits of high resolution PET.
To determine if dose-intensifying the adjuvant temozolomide component of the chemoradiation treatment enhances treatment efficacy as measured by overall survival.
To determine if denosumab is non-inferior to zoledronic acid (Zometa) with respect to the first on-study occurrence of a skeletal-related event (SRE) in subjects with advanced breast cancer and bone metastases.
The cost-effectiveness of multidisciplinary management of Tinnitus at a specialised Tinnitus Center.
The main objective of this study proposal is to examine the effectiveness, costs, and cost-effectiveness of an integral treatment provided by a specialised tinnitus center.
Primary Objective: To perform BAL in healthy volunteers, who can serve as control subjects in (future) studies.
This study investigates the effects of monitoring patient progress and the development of the therapeutic alliance from patients perspective and providing infromation to both, patients and therapists.
The main objectives are :Cross-sectional:1. To investigate the extent of atherosclerotic disease of the carotid artery defined as: (a) the intima-media thickness (IMT) (b) the elasticity (c) the degree of stenosis2. To define the degree of…
The primary objective of this study is to demonstrate that eritoran tetrasodium treatment of patients with severe sepsis results in a reduction in 28-day all-cause mortality.The secondary objectives are to confirm eritoran*s safety profile, and to…