200 results
To examine cellular damage, intestinal barrier function loss, activation of the Complement system and inflammatory alterations induced by ischemia and reperfusion of the human small and large intestine.Second, we aim to study the consequences of…
The current project aims first to examine whether IPT produces outcomes that are superior to the comprehensive treatments already available ('care as usual'). Primary outcomes include parenting behavior and the quality of the parent-child…
Evaluation of intensive therapy for relapsed B-cell lymphoma with CNS localisation. Treatment includes:a. intrathecal administration of rituximab, B. combining R-DHAP with high dose methotrexate intravenously.The following endpoints will be…
To establish normal ranges for the lateral ventricles in neonates with a gestational age ranging from 25 to 42 weeks.
We intend to study the role of fronto-striatal circuitry and cognitive control in the inflexible behaviour that is a defining feature of autism.
To determine the effects of feedback regarding patient progress on patient outcome and number of treatment sessions. Questions are::1, Is monitoring with feedback to therapists more (cost-)effective than monitoring without feedback; 2, is feedback…
To obtain insight in the role of the innate immune response, especially Type 1 interferons, in the pathogenesis of RSV LRTI. New techniques are used to unravel the local (nasopharyngeal) immunological milieu during viral LRTI. The hypothesis is that…
zie bovenstaand
To study the effect of peginterferon alpha and ribavirin on spermatozoa
To examine the safety, tolerability, and effect on glucose metabolism of metformin treatment in non-diabetic patients with TIA or minor ischemic stroke and impaired glucose tolerance.
The main objectives are :Cross-sectional:1. To investigate the extent of atherosclerotic disease of the carotid artery defined as: (a) the intima-media thickness (IMT) (b) the elasticity (c) the degree of stenosis2. To define the degree of…
• Evaluation of the safety, tolerability and immunogenicity of subcutaneous (s.c.) administration of ACZ885 in pediatric subjects with SJIA.• Assessment of the initial efficacy profile (% responder to treatment and time to relapse) according to the…
Primary:To evaluate the efficacy of 0.2 mg/kg/day of clopidogrel versus placebo for the reduction of all-cause mortality and shunt-related morbidity in neonates or infants with cyanotic congenital heart disease palliated with a systemic-to-pulmonary…
Combination therapy of steroids plus MTX induces remission faster and will therefor reduce steroid toxicity and disease damage.
The following research questions are answered in the research. I. To what extent does filling out an Implementation Intentions form influence the compliance when using `the online bewegingscoach'? II To what extent can intention be explained by…
To investigate whether cough measurements by means of VAS (0-100 points) after 6 months (+/- 6 points) in patients with chronic cough who are diagnosed and treated by a nurse practitioner outpatient clinic are equal to an outpatient clinic leaded by…
In this trial, current usual care concerning cardiovascular education is described. Second aim is to study what is understood of this education by the patient. Last aim is to study what effect training of GP's on this subject will have on the…
A randomized comparative study of the treatment of the insufficient greater saphenous vein: crossectomy with short strip vs Ultrasound guided foam sclerosis vs endovasculair laser. The Magna trial. The emphasis of this study will be on comparing the…
The aim of this study is to develop a valid and reliable instrument to estimate the extent to which gagging problems will interfere with adequate dental treatment and to evaluate possible progress after psychological treatment of gagging problems.
The aim of this study is to investigate the safety of treatment of PE in an outpatient setting based on normal pro-BNP levels. The mortality rate and the incidence of hemodynamic instability as well as major bleeding and recurrent VTE in the…