3146 results
To compare progression-free survival (PFS) between the two treatment arms based on assessments by an independent review facility (IRF).
We like to demonstrate that treatment of non-muscle invasive bladder carcinoma with incomplete TUR and IL-2 is therapeutically more effective than treatment with complete TUR and IL-2.
Organization of distinct etiological mechanisms for symptoms clinically diagnosed as SIS, into several identifiable subgroups of patients (relative cranialisation of the humerus, structural narrowing of the subacromial space, subacromial…
To assess the long-term safety and tolerability of selexipag (ACT-293987) in patients with pulmonary arterial hypertension (PAH).
In 2009, a new combination of MRI sequences was published by Deoni et al. (2009) that promised the ability to measure the myelin water in vivo over the whole head in a clinically useful time. Referred to as mcDespot (multi-component driven…
To assess whether there is a clinical relevant effect (and cost-effectiveness) in change in International Knee Documentation Committee* questionnaire over a period of 24 months of an early surgical intervention versus a more conservative management…
Primary Objective- To evaluate the long term safety and tolerability of treatment with CP-690,550 (10 mg BID or variable dose 5 and 10 mg BID) in adult subjects with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy…
1. To assess the correlation between the use of bioabsorbable anchors and the early postoperative rate of shoulder stiffness in comparison to the use of non-absorbable titanium and synthetic (PEEK) anchors in arthroscopic rotator cuff repair.2. To…
Primary: to compare inflammatory activity in atherosclerotic lesions between patients with active RA and controls, and to address the potential of anti-inflammatory therapy to reduce inflammatory atherosclerosis in RA patients.Secondary: 1] to…
To investigate the influence of different implant neck designs on marginal peri-implant bone levels and clinical variables.
Objective main studyObjectives to develop diagnostic and imaging tools to identify early RA-patients and stratify established RA-patients for individualized treatment strategies.Objective ultrasound study (amendment)-To compare inflammatory…
To evaluate anatomical changes of tumor and organs at risk with MRI before and during radiation treatment.
Primary: to develop and validate a clinical prediction rule to predict a favourable or unfavourable disease course for NP patients, therewith enabling tailor made treatments for NP patients.Secondary: determine prevalence of clinical signs of NP in…
The main aim of this implementation research is to systematically screen all RA patients of Reade rheumatology and revalidation centre in Amsterdam for their cardiovascular risk profile and if necessary to treat them for cardiovascular risk factors…
Primary objectives:- Evaluate colposcopic visual appearance of cervical lesions in relation to its histological substrate, HPV genotype(s) and molecular parameters.- Study cervical disease on the lesion level using HPV genotyping and other viral…
Treatment strategy in early HCC aims at the local removal of the tumor and represents a potentially curative treatment option (resection, liver transplantation, PEI, RFA, BT). Patients in intermediate and advanced stage of HCC receive treatment with…
In this controlled (studygroups from P05-095 will serve as controls) observational study, the effects of radiation therapy after nerve-sparing radical hysterectomy for early stage cervical cancer on sexual function, bladder and bowel function is…
Primary: Document and characterize the severe toxicity and clinical activity of the recNY-ESO-1 + AS15 ASCI in patients with NY-ESO-1-positive metastatic cutaneous melanoma.Secondary: Document and characterize additional clinical indicators of…
The primary objective is to determine which of two commonly used drugs for preoperative management provides the best intraoperative hemodynamic control in patients undergoing resection of a PCC. Secondary Objective(s): o to identify other…
The primary objective of this study is to examine the effectiveness of a short, highly structured parent based speech intervention programme on speech development in VP/VLBW children with speech sound disorder (SSD) at 2 years of age.