1152 results
The main objectives of this study are to (I) investigate characteristics of children and adolescents with CD and/or ODD in comparison with typically developing (TD) controls and (II) examine subtypes of aggression on the behavioural, cognitive,…
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic RVCL disease carriers, in order to find a *biomarker* for disease stage and progression.
The main objective is to study whether patients with elevated levels of LDL show increased H3K4 trimethylation in the promoter regions of pro-inflammatory cytokines and have an augmented ex vivo TLR agonist-induced cytokine production in isolated…
The key objectives of this study are to identify both the genetic background and pathophysiological mechanisms that underlie CSC. To achieve this we will: 1) Perform genetic analysis and ophthalmological examination in a cohort of sporadic CSC…
The goal of this stdy is to investigate both antibody responses in an invitro culture system which prevents clearance of antibodies and provides the oppertunity to study the antibodies in an antigen-free environment. This should lead to more insight…
The first objective of the study is to predict the prevalence of PH in sarcoidosis with pulmonary involvement, and to optimize the diagnostic approach in screening for PH associated sarcoidosis using the RHC as gold standard (Galie, 2009). The…
The project consists of three concrete goals:1)Compare symptoms and patterns of fatigue of visually impaired adults with a control group of adults without a visualimpairment.2)Develop an intervention aimed at treating symptoms of fatigue in visually…
The overall aim of the proposed project is to identify mild PID in elderly patients that distinguish patients with RRTI from individuals with a healthy ageing innate and adaptive immune system. In innate immunity, normal immunosenescence is…
The objective of this study is to analyse the retinal oxygenation in adults with the Oxymap T1 in patients with amblyopia and untreated or treated (vitreo-) retinopathies and compare them to a reference group of healthy eyes of amblyopic and Coats…
* To examine the effects and interactions of individual and environmental factors on the onset and course of mental health problems in adolescents and young adults.* To examine the effects and interactions of individual and environmental factors on…
To determine the effect of gastric bypass surgery on (alterations in) food preferences. Secondly, to assess the effect of gastric bypass surgery on the brain reward response when exposed to sight and smell of food stimuli with different sugar and…
To determine the add-on value of bi-atrial pacing in combination with standardised Sotalol treatment for the prevention of postoperative atrial fibrillation (POAF).
Identification of the molecular and cellular muscular mechanisms associated with aging in rotator cuff muscles with radiological quantification and clinical data.
This study had two objectives:1. which factors determine outcome of treatment of children with functional childhood constipation referred to the outpatient clinic of multidisciplinary treatment clinics in the Netherlands;2. which factors can be…
To study neuronal and ophthalmological characteristics of a newly detected clinical entity called slow vision which hampers visual perception and attention of the affected patients.
RESEARCH QUESTIONS* Is the currently used RNAF protocol for the acute medical care on the Battlefield sufficient.* What recommendation can be made to enhance this protocol, with emphasis on the transfer of information from battle field to second…
Objectives- To study presence of (Cortical) Spreading Depression ((C)SD), using direct current (DC) EEG changes in migraine patients during different phases of the migraine attack;- Is there a change in DC-EEG recordings suggestive of (C)SD,…
This project aims to achieve advances in understanding CLL initiation and progression, and to identify novel targets for therapy of CLL, through a detailed genetic and immunological comparison of manifest CLL and MBL as the premalignant counterpart…
To evaluate the cost-effectiveness of arthroscopic partial meniscectomy compared to non-operative treatment strategy. The hypothesis is that an arthroscopic partial meniscectomy is a cost-effective intervention to treat patients with clinical…
To investigate the relationship between C3 and vitamin D in adipose tissue and serum in morbidly obese subjects and in subjects who lost weight due to bariatric surgery.